Amyloidosis, AA Amyloid

Taxonomy

• Homo sapiens (Human)

Protein

• Serum amyloid p-component / Homo sapiens    P02743

Source

• Adrenal Gland (UBERON_0002369)  
• Heart (UBERON_0000948)  
• Kidney (UBERON_0002113)  
• Liver (UBERON_0002107)  
• Spleen (UBERON_0002106)  

Reported structure

• N-Linked / Complex / NeuAc(a2-?)Gal(b1-4)GlcNAc(b1-2)Man(a1-3)[NeuAc(a2-?)Gal(b1-4)GlcNAc(b1-2)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc

Composition

• Hex:5 HexNAc:4 NeuAc:2 (avg mass : 2224.0231 )

Disease

• Amyloidosis, AA Amyloid (DOID:9120)

Reference

• Human serum amyloid P component is an invariant constituent of amyloid deposits and has a uniquely homogeneous glycostructure. (1994 - Pepys M, Rademacher T, Amatayakul-Chantler S, Williams P, Noble G, Hutchinson W, Hawkins P, Nelson S, Gallimore J, Herbert J) / Status : Reviewed

Reported glycosite

• Serum amyloid p-component / Homo sapiens
  •        Asn-51

Mass spectrometry observed peptide