Diabetes Mellitus, Non-insulin dependent

Taxonomy

• Homo sapiens (Human)

Protein

• Apolipoprotein b-100 / Homo sapiens    P04114
• Forkhead box protein O1 / Homo sapiens    Q12778

Source

• Liver (UBERON_0002107)  
• Low-Density Lipoprotein Particle (GO_0034362)  

Reported structure

• N-Linked / Complex / Gal(b1-?)GlcNAc(b1-?)Man(a1-?)[GlcNAc(b1-?)Man(a1-?)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Complex / Gal(b1-?)GlcNAc(b1-?)Man(a1-3)[Gal(b1-?)GlcNAc(b1-?)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Complex / NeuAc(a2-6)Gal(b1-?)GlcNAc(b1-?)Man(a1-?)[GlcNAc(b1-?)Man(a1-?)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Complex / NeuAc(a2-?)Gal(b1-?)GlcNAc(b1-?)Man(a1-?)[GlcNAc(b1-?)Man(a1-?)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Complex / NeuAc(a2-3)Gal(b1-?)GlcNAc(b1-?)Man(a1-?)[Gal(b1-?)GlcNAc(b1-?)Man(a1-?)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Complex / NeuAc(a2-6)Gal(b1-?)GlcNAc(b1-?)Man(a1-?)[Gal(b1-?)GlcNAc(b1-?)Man(a1-?)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Complex / NeuAc(a2-3)Gal(b1-?)GlcNAc(b1-?)Man(a1-3)[NeuAc(a2-3)Gal(b1-?)GlcNAc(b1-?)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Complex / NeuAc(a2-3)Gal(b1-?)GlcNAc(b1-?)Man(a1-?)[NeuAc(a2-6)Gal(b1-?)GlcNAc(b1-?)Man(a1-?)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Complex / NeuAc(a2-6)Gal(b1-?)GlcNAc(b1-?)Man(a1-3)[NeuAc(a2-6)Gal(b1-?)GlcNAc(b1-?)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Complex / Gal(b1-?)GlcNAc(b1-?)Man(a1-6)[Gal(b1-?)GlcNAc(b1-?)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc+"+ Gal(b1-?)GlcNAc(b1-?) + NeuAc(a2-3) + NeuAc(a2-6)"
• N-Linked / High-Mannose / Man(a1-?)[Man(a1-?)]Man(a1-?)[Man(a1-?)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / High-Mannose / Man(a1-?)[Man(a1-?)]Man(a1-?)[Man(a1-?)Man(a1-?)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / High-Mannose / Man(a1-?)[Man(a1-?)]Man(a1-?)[Man(a1-?)Man(a1-?)]Man(b1-4)GlcNAc(b1-4)GlcNAc+"+ Man(a1-?)"
• N-Linked / High-Mannose / Man(a1-?)[Man(a1-?)]Man(a1-?)[Man(a1-?)Man(a1-?)Man(a1-?)]Man(b1-4)GlcNAc(b1-4)GlcNAc+"+ Man(a1-?)"
• N-Linked / High-Mannose / Man(a1-?)Man(a1-?)[Man(a1-?)Man(a1-?)]Man(a1-?)[Man(a1-?)Man(a1-?)Man(a1-?)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Hybrid / Man(a1-?)[Man(a1-?)]Man(a1-?)[GlcNAc(b1-?)Man(a1-?)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Hybrid / Man(a1-?)[Man(a1-?)]Man(a1-?)[Gal(b1-?)GlcNAc(b1-?)Man(a1-?)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Hybrid / NeuAc(a2-6)Gal(b1-?)GlcNAc(b1-?)Man(a1-?)[Man(a1-?)Man(a1-?)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• O-Linked / Undefined core / GlcNAc(b

Composition

• HexNAc:1 (avg mass : 221.2103 )
• Hex:4 HexNAc:4 (avg mass : 1479.3649 )
• Hex:4 HexNAc:4 NeuAc:1 (avg mass : 1770.6228 )
• Hex:5 HexNAc:2 (avg mass : 1235.1173 )
• Hex:5 HexNAc:3 (avg mass : 1438.3123 )
• Hex:5 HexNAc:3 NeuAc:1 (avg mass : 1729.5702 )
• Hex:5 HexNAc:4 (avg mass : 1641.5073 )
• Hex:5 HexNAc:4 NeuAc:1 (avg mass : 1932.7652 )
• Hex:5 HexNAc:4 NeuAc:2 (avg mass : 2224.0231 )
• Hex:6 HexNAc:2 (avg mass : 1397.2597 )
• Hex:6 HexNAc:3 (avg mass : 1600.4547 )
• Hex:6 HexNAc:5 NeuAc:2 (avg mass : 2589.3605 )
• Hex:7 HexNAc:2 (avg mass : 1559.4021 )
• Hex:8 HexNAc:2 (avg mass : 1721.5445 )
• Hex:9 HexNAc:2 (avg mass : 1883.6869 )

Disease

• Diabetes Mellitus, Non-insulin dependent (DOID:9352)

Reference

• O-GlcNAc Regulates FoxO Activation in Response to Glucose (2008 - Michael P Housley, Joseph T Rodgers, Namrata D Udeshi, Timothy J Kelly, Jeffrey Shabanowitz, Donald F Hunt, Pere Puigserver, Gerald W Hart) / Status : Reviewed
• Characterization of human apolipoprotein B100 oligosaccharides in LDL subfractions derived from normal and hyperlipidemic plasma: deficiency of alpha-N-acetylneuraminyllactosyl-ceramide in light and small dense LDL particles. (2001 - Garner B, Harvey DJ, Royle L, Frischmann M, Nigon F, Chapman MJ, Rudd PM) / Status : Reviewed

Reported glycosite

• Apolipoprotein b-100 / Homo sapiens
  •        Undefined site
• Forkhead box protein O1 / Homo sapiens
  •        Thr-317
  •        Ser-550
  •        Thr-648
  •        Ser-654

Mass spectrometry observed peptide

• STFRPRTSSNASTISGRLSP (20aa)
  •    Q12778    Thr-317     Forkhead box protein O1 / Homo sapiens
• PHTSGMNRL (9aa)
  •    Q12778    Ser-550     Forkhead box protein O1 / Homo sapiens
• FPHSVKTTTHSWVSG (15aa)
  •    Q12778    Ser-654     Forkhead box protein O1 / Homo sapiens
  •    Q12778    Thr-648     Forkhead box protein O1 / Homo sapiens