Wiskott-Aldrich Syndrome

Taxonomy

• Homo sapiens (Human)

Protein

• Leukosialin (cd43) / Homo sapiens    P16150

Source

• T-Lymphocyte (CL_0000084)  

Reported structure

• O-Linked / Core 1 / Gal(b1-3)GalNAc+"+ NeuAc"
• O-Linked / Core 1 / NeuAc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GalNAc
• O-Linked / Core 2 / Gal(b1-4)GlcNAc(b1-6)[Gal(b1-3)]GalNAc+"+ NeuAc(a2-3)"
• O-Linked / Core 2 / NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-3)]GalNAc

Composition

• Hex:1 HexNAc:1 NeuAc:1 (avg mass : 674.6106 )
• Hex:1 HexNAc:1 NeuAc:2 (avg mass : 965.8685 )
• Hex:2 HexNAc:2 NeuAc:1 (avg mass : 1039.948 )
• Hex:2 HexNAc:2 NeuAc:2 (avg mass : 1331.2059 )

Disease

• Wiskott-Aldrich Syndrome (DOID:9169)

Reference

• Altered O-glycan synthesis in lymphocytes from patients with Wiskott-Aldrich syndrome. (1991 - Piller F, Le Deist F, Weinberg K, Parkman R, Fukuda M) / Status : Reviewed
• Human T-lymphocyte activation is associated with changes in O-glycan biosynthesis. (1988 - Piller F, Piller V, Fox R, Fukuda M) / Status : Reviewed

Reported glycosite

• Leukosialin (cd43) / Homo sapiens
  •        Undefined site

Mass spectrometry observed peptide