Mannosidosis, alpha

Taxonomy

• Felis catus (Cat)

Protein

Source

• Brain (UBERON_0000955)  
• Urine (UBERON_0001088)  

Reported structure

• N-Linked / High-Mannose / Man(a1-2)Man(a1-3)[Man(a1-6)]Man(b1-4)GlcNAc
• N-Linked / High-Mannose / Man(a1-2)Man(a1-2)Man(a1-3)[Man(a1-6)]Man(b1-4)GlcNAc
• N-Linked / High-Mannose / Man(a1-3)[Man(a1-6)]Man(a1-6)[Man(a1-3)]Man(b1-4)GlcNAc
• N-Linked / High-Mannose / Man(a1-2)Man(a1-3)[Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / High-Mannose / Man(a1-2)Man(a1-6)[Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / High-Mannose / Man(a1-3)[Man(a1-6)]Man(a1-6)[Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / High-Mannose / Man(a1-2)Man(a1-2)Man(a1-3)[Man(a1-3)[Man(a1-6)]Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / High-Mannose / Man(a1-2)Man(a1-3)[Man(a1-6)]Man(a1-6)[Man(a1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / High-Mannose / Man(a1-2)Man(a1-6)[Man(a1-3)]Man(a1-6)[Man(a1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / No-core / Man(a1-3)Man(b1-4)GlcNAc
• N-Linked / No-core / Man(a1-6)Man(b1-4)GlcNAc
• N-Linked / No-core / Man(a1-2)Man(a1-3)Man(b1-4)GlcNAc
• N-Linked / No-core / Man(a1-3)[Man(a1-6)]Man(b1-4)GlcNAc
• N-Linked / No-core / Man(a1-3)Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / No-core / Man(a1-6)Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / No-core / Man(a1-2)Man(a1-2)Man(a1-3)Man(b1-4)GlcNAc
• N-Linked / No-core / Man(a1-2)Man(a1-6)Man(a1-6)Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / No-core / Man(a1-3)[Man(a1-6)]Man(a1-6)Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Pauci-Mannose / Man(a1-3)[Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc

Composition

• Hex:2 HexNAc:1 (avg mass : 545.4951 )
• Hex:2 HexNAc:2 (avg mass : 748.6901 )
• Hex:3 HexNAc:1 (avg mass : 707.6375 )
• Hex:3 HexNAc:2 (avg mass : 910.8325 )
• Hex:4 HexNAc:1 (avg mass : 869.7799 )
• Hex:4 HexNAc:2 (avg mass : 1072.9749 )
• Hex:5 HexNAc:1 (avg mass : 1031.9223 )
• Hex:5 HexNAc:2 (avg mass : 1235.1173 )
• Hex:7 HexNAc:2 (avg mass : 1559.4021 )

Disease

• Mannosidosis, alpha (DOID:3413)

Reference

• Different oligosaccharides accumulate in the brain and urine of a cat with alpha-mannosidosis: structure determination of five brain-derived and seventeen urinary oligosaccharides. (1991 - Hard K, Mekking A, Kamerling J, Dacremont G, Vliegenthart J) / Status : Reviewed

Reported glycosite

Mass spectrometry observed peptide