Hex:4 HexNAc:9

Taxonomy

• Homo sapiens (Human)

Protein

• Complement factor h / Homo sapiens    P08603
• Decorin / Homo sapiens    P07585
• Epithelial cell adhesion molecule / Homo sapiens    P16422
• Golgi apparatus protein 1 / Homo sapiens    Q92896
• Histidine-rich glycoprotein / Homo sapiens    P04196
• Lysosome-associated membrane glycoprotein 1 / Homo sapiens    P11279
• Polymeric immunoglobulin receptor / Homo sapiens    P01833
• Polypeptide N-acetylgalactosaminyltransferase 3 / Homo sapiens    Q14435
• Prothrombin / Homo sapiens    P00734
• Serotransferrin / Homo sapiens    P02787

Source

• Blood Serum (UBERON_0001977)  
• Mammary Gland (UBERON_0001911)  
• Milk (UBERON_0001913)  

Reported structure

• N-Linked / Complex / Structure 9375
• N-Linked / Undefined core / HexNAc(??-?)HexNAc(??-?)[Hex(??-?)HexNAc(??-?)]Hex(??-?)[HexNAc(??-?)HexNAc(??-?)[HexNAc(??-?)HexNAc(??-?)]Hex(??-?)]Hex(??-?)HexNAc(??-?)HexNAc

Composition

• Hex:4 HexNAc:9 (avg mass : 2495.3399 )

Disease

• Cancer, breast (DOID:1612)
• Oral squamous cell carcinoma (DOID:0050866)

Reference

• Quantitative Longitudinal Inventory of the N-Glycoproteome of Human Milk from a Single Donor Reveals the Highly Variable Repertoire and Dynamic Site-Specific Changes (2020 - Jing Zhu, Yu-Hsien Lin, Kelly A Dingess, Marko Mank, Bernd Stahl, Albert J R Heck) / Status : Reviewed
• Tongue Cancer Patients Can be Distinguished from Healthy Controls by Specific N-Glycopeptides Found in Serum. (2018 - Mayank Saraswat, Antti Mäkitie, Tiialotta Tohmola, Amy Dickinson, Shruti Saraswat, Sakari Joenväärä, Suvi Renkonen) / Status : Reviewed
• Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018 - Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang) / Status : Unreviewed

Reported glycosite

• Complement factor h / Homo sapiens
  •        Asn-911
• Decorin / Homo sapiens
  •        Asn-211
• Epithelial cell adhesion molecule / Homo sapiens
  •        Asn-74
• Golgi apparatus protein 1 / Homo sapiens
  •        Asn-165
• Histidine-rich glycoprotein / Homo sapiens
  •        Asn-63
• Lysosome-associated membrane glycoprotein 1 / Homo sapiens
  •        Asn-261
• Polymeric immunoglobulin receptor / Homo sapiens
  •        Asn-499
• Polypeptide N-acetylgalactosaminyltransferase 3 / Homo sapiens
  •        Asn-132
• Prothrombin / Homo sapiens
  •        Asn-143
• Serotransferrin / Homo sapiens
  •        Asn-432

Mass spectrometry observed peptide

• IADAHIDRVENTTVYYIVIDVQESDCSVISR (31aa)
  •    P04196    Asn-63     Histidine-rich glycoprotein / Homo sapiens
• AEMNGSK (7aa)
  •    P16422    Asn-74     Epithelial cell adhesion molecule / Homo sapiens
• TTNLSVEEQK (10aa)
  •    Q14435    Asn-132     Polypeptide N-acetylgalactosaminyltransferase 3 / Homo sapiens
• YPHKPEINSTTHPGADLQENFCR (23aa)
  •    P00734    Asn-143     Prothrombin / Homo sapiens
• LNLTTDPK (8aa)
  •    Q92896    Asn-165     Golgi apparatus protein 1 / Homo sapiens
• IADTNITSIPQGIPPSITEIHIDGNK (26aa)
  •    P07585    Asn-211     Decorin / Homo sapiens
• IININPNK (8aa)
  •    P11279    Asn-261     Lysosome-associated membrane glycoprotein 1 / Homo sapiens
• CGLVPVLAENYNKSDNCEDTPEAGYFAVAVVK (32aa)
  •    P02787    Asn-432     Serotransferrin / Homo sapiens
  •    VAR_058199   448:I→V   dbSNP:rs2692696
• KWNNTGCQALPSQDEGPSKA (20aa)
  •    P01833    Asn-499     Polymeric immunoglobulin receptor / Homo sapiens
• ISEENETTCYMGK (13aa)
  •    P08603    Asn-911     Complement factor h / Homo sapiens