Hex:9 HexNAc:6 dHex:1 NeuAc:2

Taxonomy

• Homo sapiens (Human)
• Bos taurus (Bovine)
• Mus musculus (House mouse)

Protein

• Alpha-2-HS-glycoprotein / Homo sapiens    P02765
• Attractin / Homo sapiens    O75882
• Kininogen-1 / Homo sapiens    P01042
• Lysosome membrane protein 2 / Homo sapiens    Q14108
• Lysosome-associated membrane glycoprotein 2 / Homo sapiens    P13473
• N-acetylglucosamine-6-sulfatase / Homo sapiens    P15586
• Sodium/potassium-transporting ATPase subunit beta-1 / Homo sapiens    P05026
• Thioredoxin domain-containing protein 15 / Homo sapiens    Q96J42
• Uromodulin / Homo sapiens    P07911
• Uncharacterized protein / Bos taurus    
• Lysosome-associated membrane glycoprotein 1 / Mus musculus    P11438

Source

• Brain (UBERON_0000955)  
• Mammary Gland (UBERON_0001911)  
• Urine (UBERON_0001088)  
• Plasma Membrane (GO_0005886)  

Reported structure

• N-Linked / Complex / NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-2)[NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-6)]Man(a1-3)[Gal(b1-3)Gal(b1-4)GlcNAc(b1-2)[Gal(b1-3)Gal(b1-4)GlcNAc(b1-4)]Man(a1-6)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc

Composition

• Hex:9 HexNAc:6 dHex:1 NeuAc:2 (avg mass : 3425.1257 )

Disease

• Cancer, breast (DOID:1612)
• Prostate cancer (DOID:10283)

Reference

• Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis (2019 - Nicholas M. Riley, Alexander S. Hebert, Michael S. Westphall & Joshua J. Coon ) / Status : Unreviewed
• Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018 - Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang) / Status : Unreviewed
• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed
• The asparagine-linked sugar chains of the glycoproteins in calf thymocyte plasma membrane. Structural studies of acidic oligosaccharides. (1980 - Yoshima H, Takasaki S, Kobata A) / Status : Reviewed

Reported glycosite

• Alpha-2-HS-glycoprotein / Homo sapiens
  •        Asn-176
• Attractin / Homo sapiens
  •        Asn-914
• Kininogen-1 / Homo sapiens
  •        Asn-294
• Lysosome membrane protein 2 / Homo sapiens
  •        Asn-206
• Lysosome-associated membrane glycoprotein 2 / Homo sapiens
  •        Asn-32
• N-acetylglucosamine-6-sulfatase / Homo sapiens
  •        Asn-111
• Sodium/potassium-transporting ATPase subunit beta-1 / Homo sapiens
  •        Asn-265
• Thioredoxin domain-containing protein 15 / Homo sapiens
  •        Asn-181
• Uromodulin / Homo sapiens
  •        Asn-513
• Uncharacterized protein / Bos taurus
  •        Undefined site
• Lysosome-associated membrane glycoprotein 1 / Mus musculus
  •        Asn-78

Mass spectrometry observed peptide

• LELNLTDSENATCLYAK (17aa)
  •    P13473    Asn-32     Lysosome-associated membrane glycoprotein 2 / Homo sapiens
• ENVSDPSLTITFGR (14aa)
  •    P11438    Asn-78     Lysosome-associated membrane glycoprotein 1 / Mus musculus
• YPHNHHVVNNTIEGNCSSK (19aa)
  •    P15586    Asn-111     N-acetylglucosamine-6-sulfatase / Homo sapiens
• AALAAFNAQNNGSNFQLEEISR (22aa)
  •    P02765    Asn-176     Alpha-2-HS-glycoprotein / Homo sapiens
• NITGLENFTLK (11aa)
  •    Q96J42    Asn-181     Thioredoxin domain-containing protein 15 / Homo sapiens
• NGTNDGDYVFITGEDSYINFTK (22aa)
  •    Q14108    Asn-206     Lysosome membrane protein 2 / Homo sapiens
• YIQPIIAVQFTNITMDTEIR (20aa)
  •    P05026    Asn-265     Sodium/potassium-transporting ATPase subunit beta-1 / Homo sapiens
• LNAENNATFYFK (12aa)
  •    P01042    Asn-294     Kininogen-1 / Homo sapiens
• FALLMTNCYATPSSNATDPLK (21aa)
  •    P07911    Asn-513     Uromodulin / Homo sapiens
• AATCINPINGSVCERPANHSAK (22aa)
  •    O75882    Asn-914     Attractin / Homo sapiens