Hex:5 HexNAc:6 dHex:3

Taxonomy

• Homo sapiens (Human)
• Mus musculus (House mouse)
• Ovis aries (Sheep)
• Rattus norvegicus (Norway rat)
• Sus scrofa (Pig)

Protein

• Alpha-1-antitrypsin / Homo sapiens    P01009
• CD59 glycoprotein / Homo sapiens    P13987
• Epidermal growth factor receptor / Homo sapiens    P00533
• Protein AMBP / Homo sapiens    P02760
• Unspecified mucin / Homo sapiens    
• Major prion protein (VRQ/VRQ polymorphism) 21K slow variant / Ovis aries    Q712V9
• Major prion protein (VRQ/VRQ polymorphism) CH1641 variant / Ovis aries    Q712V9
• Mucin / Sus scrofa    

Source

• Brain (UBERON_0000955)  
• Cerebellum (UBERON_0002037)  
• Cerebrospinal Fluid (UBERON_0001359)  
• Frontal Cortex (UBERON_0001870)  
• Hippocampul formation (UBERON:0002421)  
• Mammalian Vulva (UBERON_0000997)   A-431 (CVCL_0037)  
• Prefrontal Cortex (UBERON:0000451)  
• Pulmonary Mucosa  
• Striatum (UBERON_0002345)  
• Urine (UBERON_0001088)  

Reported structure

• N-Linked / Complex / GlcNAc(b1-2)[GlcNAc(b1-6)]Man(a1-6)[GlcNAc(b1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc+"+ Fuc(a1-2)[GalNAc(a1-3)]Gal(b1-4) + Fuc(a1-2)Gal(b1-4)"
• N-Linked / Complex / Structure 9986
• N-Linked / Complex / Structure 11469
• N-Linked / Complex / Structure 11649
• N-Linked / Complex / Structure 11687
• N-Linked / Complex / Structure 11773
• N-Linked / Complex / Structure 11845
• O-Linked / Core 2 / Fuc(a1-2)[GalNAc(a1-3)]Gal(b1-4)GlcNAc(b1-3)[Fuc(a1-2)Gal(b1-4)GlcNAc(b1-6)]Gal(b1-4)GlcNAc(b1-3)Gal(b1-3)[Fuc(a1-2)Gal(b1-4)GlcNAc(b1-6)]GalNAc
• O-Linked / Core 2 / Fuc(a1-2)Gal(b1-4)GlcNAc(b1-6)[Fuc(a1-2)Gal(b1-?)GlcNAc(b1-3)]Gal(b1-?)GlcNAc(b1-3)Gal(b1-3)[Fuc(a1-2)[GalNAc(a1-3)]Gal(b1-4)GlcNAc(b1-6)]GalNAc

Composition

• Hex:5 HexNAc:6 dHex:3 (avg mass : 2486.3263 )

Disease

• Alzheimer's disease (DOID:10652)
• Carcinoma, Squamous cell (DOID:1749)
• Control/Healthy
• Cystic Fibrosis (DOID:1485)
• Mild Cognitive Impairment (DOID:0080832)
• Prostate cancer (DOID:10283)
• Scrapie (DOID:5434)

Reference

• Mammalian brain glycoproteins exhibit diminished glycan complexity compared to other tissues (2022 - Williams SE, Noel M, Lehoux S, Cetinbas M, Xavier RJ, Sadreyev RI, Scolnick EM, Smoller JW, Cummings RD, Mealer RG) / Status : Reviewed
• Site-specific analysis of N-glycans from different sheep prion strains (2021 - Natali Nakić ,Thanh Hoa Tran ,Mislav Novokmet,Olivier Andreoletti,Gordan Lauc,Giuseppe Legname) / Status : Reviewed
• Spatial and temporal diversity of glycome expression in mammalian brain (2020 - Lee J, Ha S, Kim M, Kim SW, Yun J, Ozcan S, Hwang H, Ji IJ, Yin D, Webster MJ, Shannon Weickert C, Kim JH, Yoo JS, Grimm R, Bahn S, Shin HS, An HJ) / Status : Reviewed
• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed
• CSF N-glycoproteomics for early diagnosis in Alzheimer's disease (2016 - Palmigiano A, Barone R, Sturiale L, Sanfilippo C, Bua RO, Romeo DA, Messina A, Capuana ML, Maci T, Le Pira F, Zappia M, Garozzo D) / Status : Reviewed
• Characterization of the carbohydrate chains of the secreted form of the human epidermal growth factor receptor. (2000 - Stroop C, Weber W, Gerwig G, Nimtz M, Kamerling J, Vliegenthart J) / Status : Reviewed
• Neutral N-glycans in adult rat brain tissue--complete characterisation reveals fucosylated hybrid and complex structures (1998 - Chen YJ, Wing DR, Guile GR, Dwek RA, Harvey DJ, Zamze S) / Status : Reviewed
• Quantitation and structures of oligosaccharide chains in human trachea mucin glycoproteins. (1992 - Sangadala S, Bhat U, Mendicino J) / Status : Reviewed
• Structures of the oligosaccharide chains in swine trachea mucin glycoproteins. (1984 - Chandrasekaran EV, Rana SS, Davila M, Mendicino J) / Status : Reviewed

Reported glycosite

• Alpha-1-antitrypsin / Homo sapiens
  •        Thr-273
• CD59 glycoprotein / Homo sapiens
  •        Thr-40
• Epidermal growth factor receptor / Homo sapiens
  •        Undefined site
• Protein AMBP / Homo sapiens
  •        Thr-252
  •        Thr-258
• Unspecified mucin / Homo sapiens
  •        Undefined site
• Major prion protein (VRQ/VRQ polymorphism) 21K slow variant / Ovis aries
  •        Asn-184
• Major prion protein (VRQ/VRQ polymorphism) CH1641 variant / Ovis aries
  •        Asn-184
• Mucin / Sus scrofa
  •        Undefined site

Mass spectrometry observed peptide

• TAVNCSSDFDACLITK (16aa)
  •    P13987    Thr-40     CD59 glycoprotein / Homo sapiens
• YPNQVYYRPVDQYSNQNNFVHDCVNITVK (29aa)
  •    Q712V9    Asn-184     Major prion protein (VRQ/VRQ polymorphism) 21K slow variant / Ovis aries
  •    Q712V9    Asn-184     Major prion protein (VRQ/VRQ polymorphism) CH1641 variant / Ovis aries
• YFYNGTSMACETFQYGGCMGNGNNFVTEK (29aa)
  •    P02760    Thr-252     Protein AMBP / Homo sapiens
  •    P02760    Thr-258     Protein AMBP / Homo sapiens
• YLGNATAIFFLPDEGK (16aa)
  •    P01009    Thr-273     Alpha-1-antitrypsin / Homo sapiens