Hex:5 HexNAc:6 dHex:3

Taxonomy

• Homo sapiens (Human)
• Sus scrofa (Pig)

Protein

• Alpha-1-antitrypsin / Homo sapiens    P01009
• CD59 glycoprotein / Homo sapiens    P13987
• Epidermal growth factor receptor / Homo sapiens    P00533
• Protein AMBP / Homo sapiens    P02760
• Unspecified mucin / Homo sapiens
• Mucin / Sus scrofa

Source

• Mammalian Vulva (UBERON_0000997)   A-431 (CVCL_0037)  
• Pulmonary Mucosa  
• Urine (UBERON_0001088)  

Reported structure

• N-Linked / Complex / GlcNAc(b1-2)[GlcNAc(b1-6)]Man(a1-6)[GlcNAc(b1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc+"+ Fuc(a1-2)[GalNAc(a1-3)]Gal(b1-4) + Fuc(a1-2)Gal(b1-4)"
• O-Linked / Core 2 / Fuc(a1-2)[GalNAc(a1-3)]Gal(b1-4)GlcNAc(b1-3)[Fuc(a1-2)Gal(b1-4)GlcNAc(b1-6)]Gal(b1-4)GlcNAc(b1-3)Gal(b1-3)[Fuc(a1-2)Gal(b1-4)GlcNAc(b1-6)]GalNAc
• O-Linked / Core 2 / Fuc(a1-2)Gal(b1-4)GlcNAc(b1-6)[Fuc(a1-2)Gal(b1-?)GlcNAc(b1-3)]Gal(b1-?)GlcNAc(b1-3)Gal(b1-3)[Fuc(a1-2)[GalNAc(a1-3)]Gal(b1-4)GlcNAc(b1-6)]GalNAc

Composition

• Hex:5 HexNAc:6 dHex:3 (avg mass : 2486.3263 )

Disease

• Carcinoma, Squamous cell (DOID:1749)
• Cystic Fibrosis (DOID:1485)
• Prostate cancer (DOID:10283)

Reference

• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed
• Characterization of the carbohydrate chains of the secreted form of the human epidermal growth factor receptor. (2000 - Stroop C, Weber W, Gerwig G, Nimtz M, Kamerling J, Vliegenthart J) / Status : Reviewed
• Quantitation and structures of oligosaccharide chains in human trachea mucin glycoproteins. (1992 - Sangadala S, Bhat U, Mendicino J) / Status : Reviewed
• Structures of the oligosaccharide chains in swine trachea mucin glycoproteins. (1984 - Chandrasekaran EV, Rana SS, Davila M, Mendicino J) / Status : Reviewed

Reported glycosite

• Alpha-1-antitrypsin / Homo sapiens
  •        Thr-273
• CD59 glycoprotein / Homo sapiens
  •        Thr-40
• Epidermal growth factor receptor / Homo sapiens
  •        Undefined site
• Protein AMBP / Homo sapiens
  •        Thr-252
  •        Thr-258
• Unspecified mucin / Homo sapiens
  •        Undefined site
• Mucin / Sus scrofa
  •        Undefined site

Mass spectrometry observed peptide

• TAVNCSSDFDACLITK (16aa)
  •    P13987    Thr-40
• YFYNGTSMACETFQYGGCMGNGNNFVTEK (29aa)
  •    P02760    Thr-258
• YFYNGTSMACETFQYGGCMGNGNNFVTEK (29aa)
  •    P02760    Thr-252
• YLGNATAIFFLPDEGK (16aa)
  •    P01009    Thr-273