Hex:7 HexNAc:5 dHex:1

Taxonomy

• Homo sapiens (Human)
• Bos taurus (Bovine)
• Mus musculus (House mouse)
• Rattus norvegicus (Norway rat)
• Sus scrofa (Pig)
• Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)

Protein

• CD59 glycoprotein / Homo sapiens    P13987
• Immunoglobulin heavy constant gamma 1 / Homo sapiens    P01857
• Prostaglandin-h2 d-isomerase / Homo sapiens    P41222
• Acetylcholinesterase / Bos taurus    P23795
• Ribonuclease, brain / Bos taurus    P39873
• Uncharacterized protein from Ascites / Mus musculus
• Uncharacterized protein from B-Lymphocyte / Mus musculus
• Uncharacterized protein from B-Lymphocyte (Peripheral) / Mus musculus
• Uncharacterized protein from Plasma Membrane / Mus musculus
• Uncharacterized protein from T-Lymphocyte / Mus musculus
• Uncharacterized protein from T-Lymphocyte (Peripheral) / Mus musculus
• Uncharacterized protein from T-Lymphocyte (Stimulated) / Mus musculus
• Low density lipoprotein receptor-related protein 2 / Rattus norvegicus    P98158
• Uncharacterized protein from Erythrocyte Membrane / Rattus norvegicus
• Coagulation factor VIII / Sus scrofa    P12263
• Recombinant Spike glycoprotein (HEK293) / Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)    P0DTC2

Source

• Ascitic fluid (UBERON_0007795)   EL4 (CVCL_0255)  
• Blood Plasma (UBERON_0001969)  
• Blood Serum (UBERON_0001977)  
• Brain (UBERON_0000955)  
• Urine (UBERON_0001088)  
• BW5147 (CVCL_3896)   T-Lymphocyte (CL_0000084)  
• HEK293 (CVCL_0045)  
• WEHI-231 (CVCL_0577)   B-Lymphocyte (CL_0000236)  
• B-Lymphocyte (CL_0000236)  
• Erythrocyte (CL_0000232)   Plasma Membrane (GO_0005886)  
• T-Lymphocyte (CL_0000084)  
• Microsome (GO_0005792)  
• Plasma Membrane (GO_0005886)  

Reported structure

• N-Linked / Complex / Gal(a1-3)Gal(b1-4)GlcNAc(b1-2)Man(a1-6)[Gal(b1-4)GlcNAc(b1-2)[Gal(b1-4)GlcNAc(b1-4)]Man(a1-3)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc
• N-Linked / Complex / Gal(a1-3)Gal(b1-4)GlcNAc(b1-6)[Gal(b1-4)GlcNAc(b1-2)]Man(a1-6)[Gal(b1-4)GlcNAc(b1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc
• N-Linked / Complex / Gal(b1-4)GlcNAc(b1-2)[Gal(b1-4)GlcNAc(b1-4)]Man(a1-3)[Gal(b1-4)GlcNAc(b1-2)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc+"+ Gal(a1-3)"
• N-Linked / Complex / Gal(b1-4)GlcNAc(b1-2)[Gal(b1-4)GlcNAc(b1-4)]Man(a1-?)[Gal(b1-4)GlcNAc(b1-2)Man(a1-?)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc+"+ Gal(a1-3)"
• N-Linked / Complex / Gal(b1-4)GlcNAc(b1-2)[Gal(b1-4)GlcNAc(b1-6)]Man(a1-?)[Gal(b1-4)GlcNAc(b1-2)Man(a1-?)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc+"+ Gal(a1-3)"
• N-Linked / Complex / Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)GlcNAc(b1-2)Man(a1-3)[Gal(b1-3)Gal(b1-4)GlcNAc(b1-2)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc
• N-Linked / Complex / Gal(b1-?)GlcNAc(?1-?)[Gal(b1-?)GlcNAc(?1-?)]Man(a1-?)[Gal(b1-?)GlcNAc(?1-?)Man(a1-?)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-?)]GlcNAc+"+ Gal(a1-?)"
• N-Linked / Complex / GlcNAc(b1-2)[GlcNAc(b1-?)]Man(a1-?)[GlcNAc(b1-2)Man(a1-?)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc+"+ Gal(a1-3)Gal(b1-4) + 2 x Gal(b1-4)"

Composition

• Hex:7 HexNAc:5 dHex:1 (avg mass : 2315.1301 )

Disease

• COVID-19 (DOID:0080600)
• Lymphoma, Lymphoblastic (DOID:0080147)
• Lymphoma, Thymic (DOID:10146)
• Oral squamous cell carcinoma (DOID:0050866)
• Prostate cancer (DOID:10283)

Reference

• Site-specific N-glycosylation Characterization of Recombinant SARS-CoV-2 Spike Proteins using High-Resolution Mass Spectrometry (2020 - Yong Zhang, Wanjun Zhao, Yonghong Mao, Shisheng Wang, Yi Zhong, Tao Su, Meng Gong, Xiaofeng Lu, Jingqiu Cheng, Hao Yang) / Status : Unreviewed
• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed
• Tongue Cancer Patients Can be Distinguished from Healthy Controls by Specific N-Glycopeptides Found in Serum. (2018 - Mayank Saraswat, Antti Mäkitie, Tiialotta Tohmola, Amy Dickinson, Shruti Saraswat, Sakari Joenväärä, Suvi Renkonen) / Status : Reviewed
• Characterization of the N-linked oligosaccharides of megalin (gp330) from rat kidney. (2000 - Morelle W, Haslam S, Ziak M, Roth J, Morris H, Dell A) / Status : Reviewed
• Hierarchy of post-translational modifications involved in the circulatory longevity of glycoproteins. Demonstration of concerted contributions of glycan sialylation and subunit assembly to the pharmacokinetic behavior of bovine acetylcholinesterase. (2000 - Kronman C, Chitlaru T, Elhanany E, Velan B, Shafferman A) / Status : Reviewed
• Structural study of the sugar chains of porcine factor VIII--tissue- and species-specific glycosylation of factor VIII. (1993 - Hironaka T, Furukawa K, Esmon P, Yokota T, Brown J, Sawada S, Fournel M, Kato M, Minaga T, Kobata A) / Status : Reviewed
• Cell type and maturation stage-dependent polymorphism of N-linked oligosaccharides on murine lymphocytes and lymphoma cells. (1991 - Yoshida T, Takahashi N, Nakashima I) / Status : Reviewed
• The structure of the asparagine-linked sugar chains of bovine brain ribonuclease. (1990 - Katoh H, Ohgi K, Irie M, Endo T, Kobata A) / Status : Reviewed
• The asparagine-linked sugar chains of the glycoproteins in rat erythrocyte plasma membrane--fractionation of oligosaccharides liberated by hydrazinolysis and structural studies of the neutral oligosaccharides. (1982 - Matsumoto A, Yoshima H, Maeda S, Shiraishi N, Kobata A) / Status : Reviewed

Reported glycosite

• CD59 glycoprotein / Homo sapiens
  •        Asn-43
• Immunoglobulin heavy constant gamma 1 / Homo sapiens
  •        Asn-180
• Prostaglandin-h2 d-isomerase / Homo sapiens
  •        Asn-78
• Acetylcholinesterase / Bos taurus
  •        Undefined site
• Ribonuclease, brain / Bos taurus
  •        Asn-88
• Uncharacterized protein from Ascites / Mus musculus
  •        Undefined site
• Uncharacterized protein from B-Lymphocyte / Mus musculus
  •        Undefined site
• Uncharacterized protein from B-Lymphocyte (Peripheral) / Mus musculus
  •        Undefined site
• Uncharacterized protein from Plasma Membrane / Mus musculus
  •        Undefined site
• Uncharacterized protein from T-Lymphocyte / Mus musculus
  •        Undefined site
• Uncharacterized protein from T-Lymphocyte (Peripheral) / Mus musculus
  •        Undefined site
• Uncharacterized protein from T-Lymphocyte (Stimulated) / Mus musculus
  •        Undefined site
• Low density lipoprotein receptor-related protein 2 / Rattus norvegicus
  •        Undefined site
• Uncharacterized protein from Erythrocyte Membrane / Rattus norvegicus
  •        Undefined site
• Coagulation factor VIII / Sus scrofa
  •        Undefined site
• Recombinant Spike glycoprotein (HEK293) / Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
  •        Asn-122
  •        Asn-165
  •        Asn-282
  •        Asn-343
  •        Asn-657

Mass spectrometry observed peptide

• TAVNCSSDFDACLITK (16aa)
  •    P13987    Asn-43
• SVVAPATDGGLNLTSTFLR (19aa)
  •    P41222    Asn-78
• TQSLLIVNNATNVVIK (16aa)
  •    P0DTC2    Asn-122
• VYSSANNCTFE (11aa)
  •    P0DTC2    Asn-165
• EEQYNSTYR (9aa)
  •    P01857    Asn-180
• NGTITDAVDCALDPLSE (17aa)
  •    P0DTC2    Asn-282
• NGTITDAVDCALDPLSEK (18aa)
  •    P0DTC2    Asn-282
• FPNITNLCPFGEVFNATR (18aa)
  •    P0DTC2    Asn-343
• AGCLIGAEHVNNSYECDIPIGAGICASYQTQTNSPR (36aa)
  •    P0DTC2    Asn-657