Hex:4 HexNAc:4 dHex:2 NeuAc:1

Taxonomy

• Homo sapiens (Human)

Protein

• Acid ceramidase / Homo sapiens    Q13510
• Alpha-1-antitrypsin / Homo sapiens    P01009
• Alpha-2-HS-glycoprotein / Homo sapiens    P02765
• Alpha-S1-casein / Homo sapiens    P47710
• Asporin / Homo sapiens    Q9BXN1
• Beta-2-glycoprotein 1 / Homo sapiens    P02749
• Beta-glucuronidase / Homo sapiens    P08236
• Biglycan / Homo sapiens    P21810
• Carcinoembryonic antigen-related cell adhesion molecule 5 / Homo sapiens    P06731
• CD44 antigen / Homo sapiens    P16070
• Ceruloplasmin / Homo sapiens    P00450
• Collagen alpha-1(XII) chain / Homo sapiens    Q99715
• Collagen alpha-2(VI) chain / Homo sapiens    P12110
• Complement factor h / Homo sapiens    P08603
• Decorin / Homo sapiens    P07585
• Desmocollin-2 / Homo sapiens    Q02487
• Dipeptidyl peptidase 1 / Homo sapiens    P53634
• Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B / Homo sapiens    Q8TCJ2
• Endogenous retrovirus group 3 member 1 Env polyprotein / Homo sapiens    Q14264
• Fibrinogen beta chain / Homo sapiens    P02675
• Fibronectin / Homo sapiens    P02751
• Galectin-3-binding protein / Homo sapiens    Q08380
• Gamma-glutamyl hydrolase / Homo sapiens    Q92820
• GDNF family receptor alpha-1 / Homo sapiens    P56159
• Glucosylceramidase / Homo sapiens    P04062
• Haptoglobin / Homo sapiens    P00738
• Hemopexin / Homo sapiens    P02790
• Histidine-rich glycoprotein / Homo sapiens    P04196
• Immunoglobulin heavy constant alpha 1 / Homo sapiens    P01876
• Immunoglobulin heavy constant alpha 2 / Homo sapiens    P01877
• Integrin alpha-2 / Homo sapiens    P17301
• Integrin alpha-V / Homo sapiens    P06756
• Inter-alpha-trypsin inhibitor heavy chain h2 / Homo sapiens    P19823
• Lactotransferrin / Homo sapiens    P02788
• Lumican / Homo sapiens    P51884
• Lysosome membrane protein 2 / Homo sapiens    Q14108
• Lysosome-associated membrane glycoprotein 1 / Homo sapiens    P11279
• Mammaglobin-A / Homo sapiens    Q13296
• Membrane-bound transcription factor site-1 protease / Homo sapiens    Q14703
• Olfactomedin-like protein 3 / Homo sapiens    Q9NRN5
• Periostin / Homo sapiens    Q15063
• Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 / Homo sapiens    Q02809
• Prolactin-inducible protein / Homo sapiens    P12273
• Prosaposin / Homo sapiens    P07602
• Prostaglandin-h2 d-isomerase / Homo sapiens    P41222
• Receptor tyrosine-protein kinase erbB-2 / Homo sapiens    P04626
• Serotransferrin / Homo sapiens    P02787
• Target of Nesh-SH3 / Homo sapiens    Q7Z7G0
• Translocon-associated protein subunit alpha / Homo sapiens    P43307
• Uncharacterized protein / Homo sapiens    
• UPF0577 protein KIAA1324 / Homo sapiens    Q6UXG2
• Uromodulin / Homo sapiens    P07911
• Versican core protein / Homo sapiens    P13611
• Villin-1 / Homo sapiens    P09327
• Zinc transporter ZIP6 / Homo sapiens    Q13433
• Zinc-alpha-2-glycoprotein / Homo sapiens    P25311
• Zymogen granule protein 16 homolog B / Homo sapiens    Q96DA0

Source

• Ascitic fluid (UBERON_0007795)  
• Blood Plasma (UBERON_0001969)  
• Blood Serum (UBERON_0001977)  
• Colon (UBERON_0001155)  
• Mammary Gland (UBERON_0001911)  
• Milk (UBERON_0001913)  
• Urine (UBERON_0001088)  
• LS174T (CVCL_1384)  
• LS180 (CVCL_0397)  
• Granulocyte (CL_0000094)  

Reported structure

• N-Linked / Complex / Structure 183
• N-Linked / Complex / Structure 1854
• N-Linked / Complex / Structure 9455
• N-Linked / Complex / Structure 10457
• O-Linked / Core 2 / Fuc(a1-2)Gal(b1-3)[Fuc(a1-4)]GlcNAc(b1-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-3)]GalNAc
• O-Linked / Core 2 / Fuc(a1-4)[Gal(b1-3)]GlcNAc(b1-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-3)]GalNAc
• O-Linked / Core 2 / Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-3)]GalNAc+"+ 2 x Fuc(a1-3)"

Composition

• Hex:4 HexNAc:4 dHex:2 NeuAc:1 (avg mass : 2062.9088 )

Disease

• Cancer, breast (DOID:1612)
• Colon adenocarcinoma (DOID:234)
• Prostate cancer (DOID:10283)

Reference

• Carcinoembryonic antigen glycosylation (2021 - Kolarich D) / Status : Reviewed
• Colorectal cancer cell lines show striking diversity of their O-glycome reflecting the cellular differentiation phenotype (2021 - Katarina Madunić, Tao Zhang, Oleg A Mayboroda, Stephanie Holst, Kathrin Stavenhagen, Chunsheng Jin, Niclas G Karlsson, Guinevere S M Lageveen-Kammeijer, Manfred Wuhrer) / Status : Unreviewed
• Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis (2021 - Rebeca Kawahara, Anastasia Chernykh, Kathirvel Alagesan, Marshall Bern, Weiqian Cao, Robert J. Chalkley, Kai Cheng, Matthew S. Choo, Nathan Edwards, Radoslav Goldman, Marcus Hoffmann, Yingwei Hu, Yifan Huang, Jin Young Kim, Doron Kletter, Benoit Liquet, Mingqi Liu, Yehia Mechref, Bo Meng, Sriram Neelamegham, Terry Nguyen-Khuong, Jonas Nilsson, Adam Pap, Gun Wook Park, Benjamin L. Parker, Cassandra L. Pegg, Josef M. Penninger, Toan K. Phung, Markus Pioch, Erdmann Rapp, Enes Sakalli, Miloslav Sanda, Benjamin L. Schulz, Nichollas E. Scott, Georgy Sofronov, Johannes Stadlmann, Sergey Y. Vakhrushev, Christina M. Woo, Hung-Yi Wu, Pengyuan Yang, Wantao Ying, Hui Zhang, Yong Zhang, Jingfu Zhao, Joseph Zaia, Stuart M. Haslam, Giuseppe Palmisano, Jong Shin Yoo, Göran Larson, Kai-Hooi Khoo, Katalin F. Medzihradszky, Daniel Kolarich, Nicolle H. Packer, Morten Thaysen-Andersen) / Status : Reviewed
• Quantitative Longitudinal Inventory of the N-Glycoproteome of Human Milk from a Single Donor Reveals the Highly Variable Repertoire and Dynamic Site-Specific Changes (2020 - Jing Zhu, Yu-Hsien Lin, Kelly A Dingess, Marko Mank, Bernd Stahl, Albert J R Heck) / Status : Reviewed
• Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018 - Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang) / Status : Unreviewed
• Large-scale intact glycopeptide identification by Mascot database search (2018 - Ravi Chand Bollineni, Christian Jeffrey Koehler, Randi Elin Gislefoss, Jan Haug Anonsen, Bernd Thiede) / Status : Unreviewed
• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed
• Automated assignments of N- and O-site specific glycosylation with extensive glycan heterogeneity of glycoprotein mixtures (2013 - Strum JS1, Nwosu CC, Hua S, Kronewitter SR, Seipert RR, Bachelor RJ, An HJ, Lebrilla CB) / Status : Reviewed
• Exploring site-specific N-glycosylation microheterogeneity of haptoglobin using glycopeptide CID tandem mass spectra and glycan database search (2013 - Chandler KB1, Pompach P, Goldman R, Edwards N.) / Status : Reviewed
• Primary structure of twenty three neutral and monosialylated oligosaccharides O-glycosidically linked to the human secretory immunoglobulin A hinge region determined by a combination of permethylation analysis and 400-MHz 1H-NMR spectroscopy. (1989 - Pierce-Cretel A, Decottignies J, Wieruszeski J, Strecker G, Montreuil J, Spik G) / Status : Reviewed
• Structures of O-linked oligosaccharides isolated from normal granulocytes, chronic myelogenous leukemia cells, and acute myelogenous leukemia cells. (1986 - Fukuda M, Carlsson S, Klock J, Dell A) / Status : Reviewed

Reported glycosite

• Acid ceramidase / Homo sapiens
  •        Asn-286
• Alpha-1-antitrypsin / Homo sapiens
  •        Asn-271
• Alpha-2-HS-glycoprotein / Homo sapiens
  •        Asn-156
• Alpha-S1-casein / Homo sapiens
  •        Asn-69
• Asporin / Homo sapiens
  •        Asn-282
• Beta-2-glycoprotein 1 / Homo sapiens
  •        Asn-253
• Beta-glucuronidase / Homo sapiens
  •        Asn-173
  •        Asn-272
• Biglycan / Homo sapiens
  •        Asn-270
  •        Asn-311
• Carcinoembryonic antigen-related cell adhesion molecule 5 / Homo sapiens
  •        Undefined site
• CD44 antigen / Homo sapiens
  •        Asn-57
• Ceruloplasmin / Homo sapiens
  •        Ser-360
• Collagen alpha-1(XII) chain / Homo sapiens
  •        Asn-2679
• Collagen alpha-2(VI) chain / Homo sapiens
  •        Asn-785
• Complement factor h / Homo sapiens
  •        Asn-911
• Decorin / Homo sapiens
  •        Asn-262
• Desmocollin-2 / Homo sapiens
  •        Asn-392
• Dipeptidyl peptidase 1 / Homo sapiens
  •        Asn-53
• Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B / Homo sapiens
  •        Asn-616
• Endogenous retrovirus group 3 member 1 Env polyprotein / Homo sapiens
  •        Asn-105
• Fibrinogen beta chain / Homo sapiens
  •        Asn-394
• Fibronectin / Homo sapiens
  •        Asn-528
• Galectin-3-binding protein / Homo sapiens
  •        Asn-69
• Gamma-glutamyl hydrolase / Homo sapiens
  •        Asn-307
• GDNF family receptor alpha-1 / Homo sapiens
  •        Asn-59
• Glucosylceramidase / Homo sapiens
  •        Asn-185
• Haptoglobin / Homo sapiens
  •        Asn-207
  •        Asn-211
• Hemopexin / Homo sapiens
  •        Asn-64
  •        Asn-453
• Histidine-rich glycoprotein / Homo sapiens
  •        Asn-125
• Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •        Undefined site
  •        Ser-105
• Immunoglobulin heavy constant alpha 2 / Homo sapiens
  •        Asn-205
• Integrin alpha-2 / Homo sapiens
  •        Asn-1057
• Integrin alpha-V / Homo sapiens
  •        Asn-615
• Inter-alpha-trypsin inhibitor heavy chain h2 / Homo sapiens
  •        Asn-118
• Lactotransferrin / Homo sapiens
  •        Asn-156
  •        Asn-642
• Lumican / Homo sapiens
  •        Asn-127
• Lysosome membrane protein 2 / Homo sapiens
  •        Asn-325
• Lysosome-associated membrane glycoprotein 1 / Homo sapiens
  •        Asn-249
  •        Asn-261
• Mammaglobin-A / Homo sapiens
  •        Asn-53
• Membrane-bound transcription factor site-1 protease / Homo sapiens
  •        Asn-148
• Olfactomedin-like protein 3 / Homo sapiens
  •        Asn-177
• Periostin / Homo sapiens
  •        Asn-599
• Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 / Homo sapiens
  •        Asn-538
• Prolactin-inducible protein / Homo sapiens
  •        Asn-105
• Prosaposin / Homo sapiens
  •        Asn-80
• Prostaglandin-h2 d-isomerase / Homo sapiens
  •        Ser-67
  •        Asn-78
• Receptor tyrosine-protein kinase erbB-2 / Homo sapiens
  •        Ser-998
• Serotransferrin / Homo sapiens
  •        Asn-432
  •        Asn-630
• Target of Nesh-SH3 / Homo sapiens
  •        Asn-259
• Translocon-associated protein subunit alpha / Homo sapiens
  •        Asn-136
• Uncharacterized protein / Homo sapiens
  •        Undefined site
• UPF0577 protein KIAA1324 / Homo sapiens
  •        Asn-717
• Uromodulin / Homo sapiens
  •        Thr-504
  •        Ser-511
  •        Asn-513
• Versican core protein / Homo sapiens
  •        Asn-330
• Villin-1 / Homo sapiens
  •        Asn-526
• Zinc transporter ZIP6 / Homo sapiens
  •        Asn-266
• Zinc-alpha-2-glycoprotein / Homo sapiens
  •        Asn-109
  •        Asn-128
• Zymogen granule protein 16 homolog B / Homo sapiens
  •        Asn-197

Mass spectrometry observed peptide

• DVNCSVMGPQEK (12aa)
  •    P53634    Asn-53     Dipeptidyl peptidase 1 / Homo sapiens
• ELLQEFIDDNATTNAIDELK (20aa)
  •    Q13296    Asn-53     Mammaglobin-A / Homo sapiens
• AFNSTLPTMAQMEK (14aa)
  •    P16070    Asn-57     CD44 antigen / Homo sapiens
• ETNFSIASGIEAK (13aa)
  •    P56159    Asn-59     GDNF family receptor alpha-1 / Homo sapiens
• CSDGWSFDATTLDDNGTMLFFK (22aa)
  •    P02790    Asn-64     Hemopexin / Homo sapiens
• ALGFENATQALGR (13aa)
  •    Q08380    Asn-69     Galectin-3-binding protein / Homo sapiens
• KQTDEIKDTRNESTQNCVVAEPEKM (25aa)
  •    P47710    Asn-69     Alpha-S1-casein / Homo sapiens
• SVVAPATDGGLNLTSTFLR (19aa)
  •    P41222    Asn-78     Prostaglandin-h2 d-isomerase / Homo sapiens
  •    P41222    Ser-67     Prostaglandin-h2 d-isomerase / Homo sapiens
• DNATEEEILVYLEK (14aa)
  •    P07602    Asn-80     Prosaposin / Homo sapiens
• TFYWDFYTNR (10aa)
  •    P12273    Asn-105     Prolactin-inducible protein / Homo sapiens
• HYTNPSQDVTVPCPVPSTPPTPSPSTPPTPSPSCCHPR (38aa)
  •    P01876    Ser-105     Immunoglobulin heavy constant alpha 1 / Homo sapiens
• EGDLLNQTK (9aa)
  •    Q14264    Asn-105     Endogenous retrovirus group 3 member 1 Env polyprotein / Homo sapiens
• KDIVEYYNDSNGSHVLQGRF (20aa)
  •    P25311    Asn-109     Zinc-alpha-2-glycoprotein / Homo sapiens
• GAFISNFSMTVDGK (14aa)
  •    P19823    Asn-118     Inter-alpha-trypsin inhibitor heavy chain h2 / Homo sapiens
• VIDFNCTTSSVSSAIANTK (19aa)
  •    P04196    Asn-125     Histidine-rich glycoprotein / Homo sapiens
• LHINHNNLTESVGPLPK (17aa)
  •    P51884    Asn-127     Lumican / Homo sapiens
• FGCEIENNR (9aa)
  •    P25311    Asn-128     Zinc-alpha-2-glycoprotein / Homo sapiens
• YPQDYQFYIQNFTAIPINTVVPPQR (25aa)
  •    P43307    Asn-136     Translocon-associated protein subunit alpha / Homo sapiens
• YAESDPTVPCNETR (14aa)
  •    Q14703    Asn-148     Membrane-bound transcription factor site-1 protease / Homo sapiens
• RTAGWNVPIGTLRPFLNWTGPPEPIEAAVARF (32aa)
  •    P02788    Asn-156     Lactotransferrin / Homo sapiens
• VCQDCPIIAPINDTR (15aa)
  •    P02765    Asn-156     Alpha-2-HS-glycoprotein / Homo sapiens
• ITIAINNTLTPTTLPPGTIQYLTDTSK (27aa)
  •    P08236    Asn-173     Beta-glucuronidase / Homo sapiens
• IYVIDGTQNDTAFVFPR (17aa)
  •    Q9NRN5    Asn-177     Olfactomedin-like protein 3 / Homo sapiens
• TYTYADTPDDFQIHNFSIPEEDTK (24aa)
  •    P04062    Asn-185     Glucosylceramidase / Homo sapiens
• SIGFEWNYPLEEPTTEPPVNLTYSANSPVGR (31aa)
  •    Q96DA0    Asn-197     Zymogen granule protein 16 homolog B / Homo sapiens
• TPLTANITK (9aa)
  •    P01877    Asn-205     Immunoglobulin heavy constant alpha 2 / Homo sapiens
• KNLFLNHSENATAKD (15aa)
  •    P00738    Asn-211     Haptoglobin / Homo sapiens
• KDNTTVTR (8aa)
  •    P11279    Asn-249     Lysosome-associated membrane glycoprotein 1 / Homo sapiens
• IGNWSAMPSCK (11aa)
  •    P02749    Asn-253     Beta-2-glycoprotein 1 / Homo sapiens
• QVIQNVTHK (9aa)
  •    Q7Z7G0    Asn-259     Target of Nesh-SH3 / Homo sapiens
• IININPNK (8aa)
  •    P11279    Asn-261     Lysosome-associated membrane glycoprotein 1 / Homo sapiens
• IGISFNSISAVDNGSIANTPHIR (23aa)
  •    P07585    Asn-262     Decorin / Homo sapiens
• NTNENPQECFNASK (14aa)
  •    Q13433    Asn-266     Zinc transporter ZIP6 / Homo sapiens
• MIENGSISFIPTIR (14aa)
  •    P21810    Asn-270     Biglycan / Homo sapiens
• YIGNATAIFFIPDEGK (16aa)
  •    P01009    Asn-271     Alpha-1-antitrypsin / Homo sapiens
• VVANGTGTQGQIK (13aa)
  •    P08236    Asn-272     Beta-glucuronidase / Homo sapiens
• ITDIENGSIANIPR (14aa)
  •    Q9BXN1    Asn-282     Asporin / Homo sapiens
• IIAPAYFIIGGNQSGEGCVITR (22aa)
  •    Q13510    Asn-286     Acid ceramidase / Homo sapiens
• ALIYQFSPIYTGNISSFQQ (19aa)
  •    Q92820    Asn-307     Gamma-glutamyl hydrolase / Homo sapiens
• IIQVVYIHSNNITK (14aa)
  •    P21810    Asn-311     Biglycan / Homo sapiens
• CLGSGVLNVSICK (13aa)
  •    Q14108    Asn-325     Lysosome membrane protein 2 / Homo sapiens
• FENQTGFPPPDSR (13aa)
  •    P13611    Asn-330     Versican core protein / Homo sapiens
• AGLQAFFQVQECNKSSSK (18aa)
  •    P00450    Ser-360     Ceruloplasmin / Homo sapiens
• ANYTILK (7aa)
  •    Q02487    Asn-392     Desmocollin-2 / Homo sapiens
• GTAGNAIMDGASQIMGENR (19aa)
  •    P02675    Asn-394     Fibrinogen beta chain / Homo sapiens
• CGIVPVIAENYNK (13aa)
  •    P02787    Asn-432     Serotransferrin / Homo sapiens
• AIPQPQNVTSIIGCTH (16aa)
  •    P02790    Asn-453     Hemopexin / Homo sapiens
• FALLMTNCYATPSSNATDPLK (21aa)
  •    P07911    Ser-511     Uromodulin / Homo sapiens
  •    P07911    Asn-513     Uromodulin / Homo sapiens
• FALLMTNCYATPSSNATDPLKYFIIQDR (28aa)
  •    P07911    Thr-504     Uromodulin / Homo sapiens
  •    P07911    Asn-513     Uromodulin / Homo sapiens
• LFQVQGTGANNTK (13aa)
  •    P09327    Asn-526     Villin-1 / Homo sapiens
• DQCIVDDITYNVNDTFHK (18aa)
  •    P02751    Asn-528     Fibronectin / Homo sapiens
• YIHQNYTK (8aa)
  •    Q02809    Asn-538     Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 / Homo sapiens
• EVNDTLLVNELK (12aa)
  •    Q15063    Asn-599     Periostin / Homo sapiens
• TAADTTGIQPIINQFTPANISR (22aa)
  •    P06756    Asn-615     Integrin alpha-V / Homo sapiens
• VMSWWDYGYQIAGMANR (17aa)
  •    Q8TCJ2    Asn-616     Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B / Homo sapiens
• QQQHIFGSNVTDCSGNFCIFR (21aa)
  •    P02787    Asn-630     Serotransferrin / Homo sapiens
• MSVCTDNVTDLR (12aa)
  •    Q6UXG2    Asn-717     UPF0577 protein KIAA1324 / Homo sapiens
• NMTLFSDLVAEK (12aa)
  •    P12110    Asn-785     Collagen alpha-2(VI) chain / Homo sapiens
• ISEENETTCYMGK (13aa)
  •    P08603    Asn-911     Complement factor h / Homo sapiens
• DPQRFVVIQNEDLGPASPLDSTFYR (25aa)
  •    P04626    Ser-998     Receptor tyrosine-protein kinase erbB-2 / Homo sapiens
• TASCSNVTCWIK (12aa)
  •    P17301    Asn-1057     Integrin alpha-2 / Homo sapiens
• EAGNITTDGYEIIGK (15aa)
  •    Q99715    Asn-2679     Collagen alpha-1(XII) chain / Homo sapiens