Hex:4 HexNAc:4 dHex:2 NeuAc:1

Taxonomy

• Homo sapiens (Human)

Protein

• Acid ceramidase / Homo sapiens    Q13510
• Alpha-1-antitrypsin / Homo sapiens    P01009
• Alpha-2-HS-glycoprotein / Homo sapiens    P02765
• Alpha-S1-casein / Homo sapiens    P47710
• Asporin / Homo sapiens    Q9BXN1
• Beta-2-glycoprotein 1 / Homo sapiens    P02749
• Beta-glucuronidase / Homo sapiens    P08236
• Biglycan / Homo sapiens    P21810
• CD44 antigen / Homo sapiens    P16070
• Ceruloplasmin / Homo sapiens    P00450
• Collagen alpha-1(XII) chain / Homo sapiens    Q99715
• Collagen alpha-2(VI) chain / Homo sapiens    P12110
• Complement factor h / Homo sapiens    P08603
• Decorin / Homo sapiens    P07585
• Desmocollin-2 / Homo sapiens    Q02487
• Dipeptidyl peptidase 1 / Homo sapiens    P53634
• Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B / Homo sapiens    Q8TCJ2
• Endogenous retrovirus group 3 member 1 Env polyprotein / Homo sapiens    Q14264
• Fibrinogen beta chain / Homo sapiens    P02675
• Fibronectin / Homo sapiens    P02751
• Galectin-3-binding protein / Homo sapiens    Q08380
• Gamma-glutamyl hydrolase / Homo sapiens    Q92820
• GDNF family receptor alpha-1 / Homo sapiens    P56159
• Glucosylceramidase / Homo sapiens    P04062
• Haptoglobin / Homo sapiens    P00738
• Hemopexin / Homo sapiens    P02790
• Histidine-rich glycoprotein / Homo sapiens    P04196
• Immunoglobulin alpha (secretory) / Homo sapiens    P01877    P01876
• Immunoglobulin heavy constant alpha 1 / Homo sapiens    P01876
• Immunoglobulin heavy constant alpha 2 / Homo sapiens    P01877
• Integrin alpha-2 / Homo sapiens    P17301
• Integrin alpha-V / Homo sapiens    P06756
• Inter-alpha-trypsin inhibitor heavy chain h2 / Homo sapiens    P19823
• Lactotransferrin / Homo sapiens    P02788
• Lumican / Homo sapiens    P51884
• Lysosome membrane protein 2 / Homo sapiens    Q14108
• Lysosome-associated membrane glycoprotein 1 / Homo sapiens    P11279
• Mammaglobin-A / Homo sapiens    Q13296
• Membrane-bound transcription factor site-1 protease / Homo sapiens    Q14703
• Olfactomedin-like protein 3 / Homo sapiens    Q9NRN5
• Periostin / Homo sapiens    Q15063
• Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 / Homo sapiens    Q02809
• Prolactin-inducible protein / Homo sapiens    P12273
• Prosaposin / Homo sapiens    P07602
• Prostaglandin-h2 d-isomerase / Homo sapiens    P41222
• Receptor tyrosine-protein kinase erbB-2 / Homo sapiens    P04626
• Serotransferrin / Homo sapiens    P02787
• Target of Nesh-SH3 / Homo sapiens    Q7Z7G0
• Translocon-associated protein subunit alpha / Homo sapiens    P43307
• Uncharacterized protein from Granulocyte / Homo sapiens    
• UPF0577 protein KIAA1324 / Homo sapiens    Q6UXG2
• Uromodulin / Homo sapiens    P07911
• Versican core protein / Homo sapiens    P13611
• Villin-1 / Homo sapiens    P09327
• Zinc transporter ZIP6 / Homo sapiens    Q13433
• Zinc-alpha-2-glycoprotein / Homo sapiens    P25311
• Zymogen granule protein 16 homolog B / Homo sapiens    Q96DA0

Source

• Blood Plasma (UBERON_0001969)  
• Blood Serum (UBERON_0001977)  
• Mammary Gland (UBERON_0001911)  
• Milk (UBERON_0001913)  
• Urine (UBERON_0001088)  
• Granulocyte (CL_0000094)  

Reported structure

• N-Linked / Complex / Structure 183
• N-Linked / Complex / Structure 1854
• N-Linked / Complex / Structure 9455
• O-Linked / Core 2 / Fuc(a1-2)Gal(b1-3)[Fuc(a1-4)]GlcNAc(b1-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-3)]GalNAc
• O-Linked / Core 2 / Fuc(a1-4)[Gal(b1-3)]GlcNAc(b1-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-3)]GalNAc
• O-Linked / Core 2 / Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-3)]GalNAc+"+ 2 x Fuc(a1-3)"

Composition

• Hex:4 HexNAc:4 dHex:2 NeuAc:1 (avg mass : 2062.9088 )

Disease

• Cancer, breast (DOID:1612)
• Prostate cancer (DOID:10283)

Reference

• Community Evaluation of Glycoproteomics Informatics Solutions Reveals High-Performance Search Strategies for Glycopeptide Analysis (2021 - Rebeca Kawahara, Kathirvel Alagesan, Marshall Bern, Meng Bo, Weiqian Cao, Robert J Chalkley, Kai Cheng, Matthew S. Choo, Nathan Edwards, Radoslav Goldman, Marcus Hoffmann, Yingwei Hu, Yifan Huang, Jin Young Kim, Doron Kletter, Benoit Liquet-Weiland, Mingqi Liu, Yehia Mechref, Sriram Neelamegham, Terry Nguyen-Khuong, Jonas Nilsson, Adam Pap, Gun Wook Park, Benjamin L. Parker, Cassandra L. Pegg, Josef M. Penninger, Toan K. Phung, Markus Pioch, Erdmann Rapp, Enes Sakalli, Miloslav Sanda, Benjamin L. Schulz, Nichollas Scott, Georgy Sofronov, Johannes Stadlmann, Sergey Vakhrushev, Christina Woo, Hung-Yi Wu, Pengyuan Yang, Wantao Ying, Zhang Yong, Hui Zhang, Jingfu Zhao, Joseph Zaia, Stuart M. Haslam, Giuseppe Palmisano, Jong Shin Yoo, Goran Larson, Kai-Hooi Khoo, Katalin F. Medzihradszky, Daniel Kolarich, Nicolle H. Packer, and Morten Thaysen-Andersen) / Status : Reviewed
• Quantitative Longitudinal Inventory of the N-Glycoproteome of Human Milk from a Single Donor Reveals the Highly Variable Repertoire and Dynamic Site-Specific Changes (2020 - Jing Zhu, Yu-Hsien Lin, Kelly A Dingess, Marko Mank, Bernd Stahl, Albert J R Heck) / Status : Reviewed
• Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018 - Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang) / Status : Unreviewed
• Large-scale intact glycopeptide identification by Mascot database search (2018 - Ravi Chand Bollineni, Christian Jeffrey Koehler, Randi Elin Gislefoss, Jan Haug Anonsen, Bernd Thiede) / Status : Unreviewed
• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed
• Automated assignments of N- and O-site specific glycosylation with extensive glycan heterogeneity of glycoprotein mixtures (2013 - Strum JS1, Nwosu CC, Hua S, Kronewitter SR, Seipert RR, Bachelor RJ, An HJ, Lebrilla CB) / Status : Reviewed
• Exploring site-specific N-glycosylation microheterogeneity of haptoglobin using glycopeptide CID tandem mass spectra and glycan database search (2013 - Chandler KB1, Pompach P, Goldman R, Edwards N.) / Status : Reviewed
• Primary structure of twenty three neutral and monosialylated oligosaccharides O-glycosidically linked to the human secretory immunoglobulin A hinge region determined by a combination of permethylation analysis and 400-MHz 1H-NMR spectroscopy. (1989 - Pierce-Cretel A, Decottignies J, Wieruszeski J, Strecker G, Montreuil J, Spik G) / Status : Reviewed
• Structures of O-linked oligosaccharides isolated from normal granulocytes, chronic myelogenous leukemia cells, and acute myelogenous leukemia cells. (1986 - Fukuda M, Carlsson S, Klock J, Dell A) / Status : Reviewed

Reported glycosite

• Acid ceramidase / Homo sapiens
  •        Asn-286
• Alpha-1-antitrypsin / Homo sapiens
  •        Asn-271
• Alpha-2-HS-glycoprotein / Homo sapiens
  •        Asn-156
• Alpha-S1-casein / Homo sapiens
  •        Asn-69
• Asporin / Homo sapiens
  •        Asn-282
• Beta-2-glycoprotein 1 / Homo sapiens
  •        Asn-253
• Beta-glucuronidase / Homo sapiens
  •        Asn-173
  •        Asn-272
• Biglycan / Homo sapiens
  •        Asn-270
  •        Asn-311
• CD44 antigen / Homo sapiens
  •        Asn-57
• Ceruloplasmin / Homo sapiens
  •        Ser-360
• Collagen alpha-1(XII) chain / Homo sapiens
  •        Asn-2679
• Collagen alpha-2(VI) chain / Homo sapiens
  •        Asn-785
• Complement factor h / Homo sapiens
  •        Asn-911
• Decorin / Homo sapiens
  •        Asn-262
• Desmocollin-2 / Homo sapiens
  •        Asn-392
• Dipeptidyl peptidase 1 / Homo sapiens
  •        Asn-53
• Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B / Homo sapiens
  •        Asn-616
• Endogenous retrovirus group 3 member 1 Env polyprotein / Homo sapiens
  •        Asn-105
• Fibrinogen beta chain / Homo sapiens
  •        Asn-394
• Fibronectin / Homo sapiens
  •        Asn-528
• Galectin-3-binding protein / Homo sapiens
  •        Asn-69
• Gamma-glutamyl hydrolase / Homo sapiens
  •        Asn-307
• GDNF family receptor alpha-1 / Homo sapiens
  •        Asn-59
• Glucosylceramidase / Homo sapiens
  •        Asn-185
• Haptoglobin / Homo sapiens
  •        Asn-207
  •        Asn-211
• Hemopexin / Homo sapiens
  •        Asn-64
  •        Asn-453
• Histidine-rich glycoprotein / Homo sapiens
  •        Asn-125
• Immunoglobulin alpha (secretory) / Homo sapiens
  •        Undefined site
• Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •        Ser-105
• Immunoglobulin heavy constant alpha 2 / Homo sapiens
  •        Asn-205
• Integrin alpha-2 / Homo sapiens
  •        Asn-1057
• Integrin alpha-V / Homo sapiens
  •        Asn-615
• Inter-alpha-trypsin inhibitor heavy chain h2 / Homo sapiens
  •        Asn-118
• Lactotransferrin / Homo sapiens
  •        Asn-156
  •        Asn-642
• Lumican / Homo sapiens
  •        Asn-127
• Lysosome membrane protein 2 / Homo sapiens
  •        Asn-325
• Lysosome-associated membrane glycoprotein 1 / Homo sapiens
  •        Asn-249
  •        Asn-261
• Mammaglobin-A / Homo sapiens
  •        Asn-53
• Membrane-bound transcription factor site-1 protease / Homo sapiens
  •        Asn-148
• Olfactomedin-like protein 3 / Homo sapiens
  •        Asn-177
• Periostin / Homo sapiens
  •        Asn-599
• Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 / Homo sapiens
  •        Asn-538
• Prolactin-inducible protein / Homo sapiens
  •        Asn-105
• Prosaposin / Homo sapiens
  •        Asn-80
• Prostaglandin-h2 d-isomerase / Homo sapiens
  •        Ser-67
  •        Asn-78
• Receptor tyrosine-protein kinase erbB-2 / Homo sapiens
  •        Ser-998
• Serotransferrin / Homo sapiens
  •        Asn-432
  •        Asn-630
• Target of Nesh-SH3 / Homo sapiens
  •        Asn-259
• Translocon-associated protein subunit alpha / Homo sapiens
  •        Asn-136
• Uncharacterized protein from Granulocyte / Homo sapiens
  •        Undefined site
• UPF0577 protein KIAA1324 / Homo sapiens
  •        Asn-717
• Uromodulin / Homo sapiens
  •        Thr-504
  •        Ser-511
  •        Asn-513
• Versican core protein / Homo sapiens
  •        Asn-330
• Villin-1 / Homo sapiens
  •        Asn-526
• Zinc transporter ZIP6 / Homo sapiens
  •        Asn-266
• Zinc-alpha-2-glycoprotein / Homo sapiens
  •        Asn-109
  •        Asn-128
• Zymogen granule protein 16 homolog B / Homo sapiens
  •        Asn-197

Mass spectrometry observed peptide

• DVNCSVMGPQEK (12aa)
  •    P53634    Asn-53
• ELLQEFIDDNATTNAIDELK (20aa)
  •    Q13296    Asn-53
• AFNSTLPTMAQMEK (14aa)
  •    P16070    Asn-57
• ETNFSIASGIEAK (13aa)
  •    P56159    Asn-59
• CSDGWSFDATTLDDNGTMLFFK (22aa)
  •    P02790    Asn-64
• ALGFENATQALGR (13aa)
  •    Q08380    Asn-69
• KQTDEIKDTRNESTQNCVVAEPEKM (25aa)
  •    P47710    Asn-69
• SVVAPATDGGLNLTSTFLR (19aa)
  •    P41222    Asn-78
  •    P41222    Ser-67
• DNATEEEILVYLEK (14aa)
  •    P07602    Asn-80
• TFYWDFYTNR (10aa)
  •    P12273    Asn-105
• HYTNPSQDVTVPCPVPSTPPTPSPSTPPTPSPSCCHPR (38aa)
  •    P01876    Ser-105
• EGDLLNQTK (9aa)
  •    Q14264    Asn-105
• KDIVEYYNDSNGSHVLQGRF (20aa)
  •    P25311    Asn-109
• GAFISNFSMTVDGK (14aa)
  •    P19823    Asn-118
• VIDFNCTTSSVSSAIANTK (19aa)
  •    P04196    Asn-125
• LHINHNNLTESVGPLPK (17aa)
  •    P51884    Asn-127
• FGCEIENNR (9aa)
  •    P25311    Asn-128
• YPQDYQFYIQNFTAIPINTVVPPQR (25aa)
  •    P43307    Asn-136
• YAESDPTVPCNETR (14aa)
  •    Q14703    Asn-148
• RTAGWNVPIGTLRPFLNWTGPPEPIEAAVARF (32aa)
  •    P02788    Asn-156
• VCQDCPIIAPINDTR (15aa)
  •    P02765    Asn-156
• ITIAINNTLTPTTLPPGTIQYLTDTSK (27aa)
  •    P08236    Asn-173
• IYVIDGTQNDTAFVFPR (17aa)
  •    Q9NRN5    Asn-177
• TYTYADTPDDFQIHNFSIPEEDTK (24aa)
  •    P04062    Asn-185
• SIGFEWNYPLEEPTTEPPVNLTYSANSPVGR (31aa)
  •    Q96DA0    Asn-197
• TPLTANITK (9aa)
  •    P01877    Asn-205
• KNLFLNHSENATAKD (15aa)
  •    P00738    Asn-211
• KDNTTVTR (8aa)
  •    P11279    Asn-249
• IGNWSAMPSCK (11aa)
  •    P02749    Asn-253
• QVIQNVTHK (9aa)
  •    Q7Z7G0    Asn-259
• IININPNK (8aa)
  •    P11279    Asn-261
• IGISFNSISAVDNGSIANTPHIR (23aa)
  •    P07585    Asn-262
• NTNENPQECFNASK (14aa)
  •    Q13433    Asn-266
• MIENGSISFIPTIR (14aa)
  •    P21810    Asn-270
• YIGNATAIFFIPDEGK (16aa)
  •    P01009    Asn-271
• VVANGTGTQGQIK (13aa)
  •    P08236    Asn-272
• ITDIENGSIANIPR (14aa)
  •    Q9BXN1    Asn-282
• IIAPAYFIIGGNQSGEGCVITR (22aa)
  •    Q13510    Asn-286
• ALIYQFSPIYTGNISSFQQ (19aa)
  •    Q92820    Asn-307
• IIQVVYIHSNNITK (14aa)
  •    P21810    Asn-311
• CLGSGVLNVSICK (13aa)
  •    Q14108    Asn-325
• FENQTGFPPPDSR (13aa)
  •    P13611    Asn-330
• AGLQAFFQVQECNKSSSK (18aa)
  •    P00450    Ser-360
• ANYTILK (7aa)
  •    Q02487    Asn-392
• GTAGNAIMDGASQIMGENR (19aa)
  •    P02675    Asn-394
• CGIVPVIAENYNK (13aa)
  •    P02787    Asn-432
• AIPQPQNVTSIIGCTH (16aa)
  •    P02790    Asn-453
• FALLMTNCYATPSSNATDPLK (21aa)
  •    P07911    Asn-513
  •    P07911    Ser-511
• FALLMTNCYATPSSNATDPLKYFIIQDR (28aa)
  •    P07911    Asn-513
  •    P07911    Thr-504
• LFQVQGTGANNTK (13aa)
  •    P09327    Asn-526
• DQCIVDDITYNVNDTFHK (18aa)
  •    P02751    Asn-528
• YIHQNYTK (8aa)
  •    Q02809    Asn-538
• EVNDTLLVNELK (12aa)
  •    Q15063    Asn-599
• TAADTTGIQPIINQFTPANISR (22aa)
  •    P06756    Asn-615
• VMSWWDYGYQIAGMANR (17aa)
  •    Q8TCJ2    Asn-616
• QQQHIFGSNVTDCSGNFCIFR (21aa)
  •    P02787    Asn-630
• MSVCTDNVTDLR (12aa)
  •    Q6UXG2    Asn-717
• NMTLFSDLVAEK (12aa)
  •    P12110    Asn-785
• ISEENETTCYMGK (13aa)
  •    P08603    Asn-911
• DPQRFVVIQNEDLGPASPLDSTFYR (25aa)
  •    P04626    Ser-998
• TASCSNVTCWIK (12aa)
  •    P17301    Asn-1057
• EAGNITTDGYEIIGK (15aa)
  •    Q99715    Asn-2679