Hex:2 HexNAc:4

Taxonomy

• Homo sapiens (Human)
• Bos taurus (Bovine)
• Macaca radiata (Bonnet macaque)
• Rattus norvegicus (Norway rat)
• Sus scrofa (Pig)

Protein

• CD59 glycoprotein / Homo sapiens    P13987
• Immunoglobulin heavy constant alpha 1 / Homo sapiens    P01876
• Mucin-2 / Homo sapiens    Q02817
• Uncharacterized protein from Meconium / Homo sapiens    
• Unspecified mucin / Homo sapiens    
• Thyrotropin-aplha and beta chains / Bos taurus    P01223    P01217
• Mucin / Macaca radiata    
• Mucin / Rattus norvegicus    
• Mucin / Sus scrofa    
• Uncharacterized protein from Epithelium of Stomach / Sus scrofa    

Source

• Blood Serum (UBERON_0001977)  
• Cervical Mucosa (UBERON_0012248)  
• Colonic Mucosa (UBERON_0000317)  
• Duodenal Gland (UBERON_0001212)  
• Epithelium of Stomach (UBERON_0001276)  
• Meconium (UBERON_0007109)  
• Mucosa of Stomach (UBERON_0001199)  
• Pituitary Gland (UBERON_0000007)  
• Striatum (UBERON_0002345)  
• Urine (UBERON_0001088)  

Reported structure

• N-Linked / No-core / GalNAc(?1-?)GlcNAc(?1-?)Man(a1-?)Man(b1-4)GlcNAc(b1-4)GlcNAc
• O-Linked / Core 2 / GlcNAc(a1-4)Gal(b1-4)GlcNAc(b1-6)[GlcNAc(a1-4)Gal(b1-3)]GalNAc
• O-Linked / Core 2 / Structure 11388
• O-Linked / Core 3 / Gal(b1-4)GlcNAc(b1-3)[GlcNAc(b1-6)]Gal(b1-4)GlcNAc(b1-3)GalNAc
• O-Linked / Core 3 / GlcNAc(b1-3)Gal(b1-?)GlcNAc(b1-3)Gal(b1-?)GlcNAc(b1-3)GalNAc
• O-Linked / Undefined core / GalNAc(?1-4)Gal(b1-4)GlcNAc(b1-?)[GalNAc(?1-3)Gal(b1-?)]GalNAc

Composition

• Hex:2 HexNAc:4 (avg mass : 1155.0801 )

Disease

• Control/Healthy
• Diverticulosis (DOID:7475)
• Parkinson's disease (DOID:14330)
• Prostate cancer (DOID:10283)

Reference

• Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis (2021 - Rebeca Kawahara, Anastasia Chernykh, Kathirvel Alagesan, Marshall Bern, Weiqian Cao, Robert J. Chalkley, Kai Cheng, Matthew S. Choo, Nathan Edwards, Radoslav Goldman, Marcus Hoffmann, Yingwei Hu, Yifan Huang, Jin Young Kim, Doron Kletter, Benoit Liquet, Mingqi Liu, Yehia Mechref, Bo Meng, Sriram Neelamegham, Terry Nguyen-Khuong, Jonas Nilsson, Adam Pap, Gun Wook Park, Benjamin L. Parker, Cassandra L. Pegg, Josef M. Penninger, Toan K. Phung, Markus Pioch, Erdmann Rapp, Enes Sakalli, Miloslav Sanda, Benjamin L. Schulz, Nichollas E. Scott, Georgy Sofronov, Johannes Stadlmann, Sergey Y. Vakhrushev, Christina M. Woo, Hung-Yi Wu, Pengyuan Yang, Wantao Ying, Hui Zhang, Yong Zhang, Jingfu Zhao, Joseph Zaia, Stuart M. Haslam, Giuseppe Palmisano, Jong Shin Yoo, Göran Larson, Kai-Hooi Khoo, Katalin F. Medzihradszky, Daniel Kolarich, Nicolle H. Packer, Morten Thaysen-Andersen) / Status : Reviewed
• The O-Glycome of Human Nigrostriatal Tissue and Its Alteration in Parkinson's Disease. (2021 - Wilkinson H, Thomsson KA, Rebelo AL, Hilliard M, Pandit A, Rudd PM, Karlsson NG, Saldova R.) / Status : Unreviewed
• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed
• Extension of the in-gel release method for structural analysis of neutral and sialylated N-linked glycans to the analysis of sulfated glycans: application to the glycans from bovine thyroid-stimulating hormone (2001 - Wheeler, Harvey) / Status : Reviewed
• Peripheral alpha-linked N-acetylglucosamine on the carbohydrate moiety of mucin derived from mammalian gastric gland mucous cells: epitope recognized by a newly characterized monoclonal antibody. (1996 - Ishihara K, Kurihara M, Goso Y, Urata T, Ota H, Katsuyama T, Hotta K) / Status : Reviewed
• Characterisation of minor tetra- to hepta-saccharides O-linked to human meconium glycoproteins by t.l.c.-m.s. microsequencing of neoglycolipid derivatives in conjunction with conventional m.s. and 1H-n.m.r. spectroscopy. (1991 - Lawson A, Hounsell E, Stoll M, Feeney J, Chai W, Rosankiewicz J, Feizi T) / Status : Reviewed
• Studies on cervical glycoproteins. Isolation and characterization of neutral oligosaccharides from pronase-treated glycoproteins of bonnet monkey (Macaca radiata). (1990 - Nasir-ud-Din , Hussain SA, Jeanloz RW, Walker-Nasir E) / Status : Reviewed
• Structures of O-glycosidically linked oligosaccharides isolated from human meconium glycoproteins. (1989 - Capon C, Leroy Y, Wieruszeski J, Ricart G, Strecker G, Montreuil J, Fournet B) / Status : Reviewed
• Oligosaccharide structures of human colonic mucin. (1985 - Podolsky D) / Status : Reviewed
• Terminal alpha (1 leads to 4)-linked N-acetylglucosamine: a characteristic constituent of duodenal-gland mucous glycoproteins in rat and pig. A high-resolution 1H-NMR study. (1983 - van Halbeek H, Gerwig G, Vliegenthart J, Smits H, Van Kerkhof P, Kramer M) / Status : Reviewed
• Characterization of the primary structure and the microheterogeneity of the carbohydrate chains of porcine blood-group H substance by 500-MHz 1H-NMR spectroscopy. (1982 - van Halbeek H, Dorland L, Vliegenthart J, Kochetkov N, Arbatsky N, Derevitskaya V) / Status : Reviewed

Reported glycosite

• CD59 glycoprotein / Homo sapiens
  •        Thr-105
• Immunoglobulin heavy constant alpha 1 / Homo sapiens
  •        Thr-109
• Mucin-2 / Homo sapiens
  •        Undefined site
• Uncharacterized protein from Meconium / Homo sapiens
  •        Undefined site
• Unspecified mucin / Homo sapiens
  •        Undefined site
• Thyrotropin-aplha and beta chains / Bos taurus
  •        Undefined site
• Mucin / Macaca radiata
  •        Undefined site
• Mucin / Rattus norvegicus
  •        Undefined site
• Mucin / Sus scrofa
  •        Undefined site
• Uncharacterized protein from Epithelium of Stomach / Sus scrofa
  •        Undefined site

Mass spectrometry observed peptide

• DLCNFNEQLENGGTSLSEK (19aa)
  •    P13987    Thr-105     CD59 glycoprotein / Homo sapiens
• HYTNPSQDVTVPCPVPSTPPTPSPSTPPTPSPSCCHPR (38aa)
  •    P01876    Thr-109     Immunoglobulin heavy constant alpha 1 / Homo sapiens