Hex:7 HexNAc:6 NeuAc:3 NeuGc:1

Taxonomy

• Homo sapiens (Human)
• Ovis aries (Sheep)

Protein

• CD59 glycoprotein / Homo sapiens    P13987
• Icos ligand / Homo sapiens    O75144
• Uromodulin / Homo sapiens    P07911
• Alpha-1-acid glycoprotein / Ovis aries    W5P7S6

Source

• Blood Serum (UBERON_0001977)  
• Urine (UBERON_0001088)  

Reported structure

• N-Linked / Complex / Gal(b1-4)GlcNAc(?1-?)[Gal(b1-4)GlcNAc(?1-?)]Man(a1-?)[Gal(b1-4)GlcNAc(?1-?)Man(a1-?)]Man(b1-4)GlcNAc(b1-4)GlcNAc+"+ Gal(b1-4)GlcNAc(?1-?) + 3 x NeuAc(a2-?) + NeuGc(a2-?)"

Composition

• Hex:7 HexNAc:6 NeuAc:3 NeuGc:1 (avg mass : 3553.2131 )

Disease

• Prostate cancer (DOID:10283)

Reference

• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed
• Structural determination of N-linked carbohydrates by matrix-assisted laser desorption/ionization-mass spectrometry following enzymatic release within sodium dodecyl sulfate-polyacrylamide electrophoresis gels: application to species-specific glycosylation of alpha1-acid glycoprotein. (1998 - Kuster B, Hunter A, Wheeler S, Dwek R, Harvey D) / Status : Reviewed

Reported glycosite

• CD59 glycoprotein / Homo sapiens
  •        Asn-43
• Icos ligand / Homo sapiens
  •        Asn-102
• Uromodulin / Homo sapiens
  •        Asn-322
• Alpha-1-acid glycoprotein / Ovis aries
  •        Undefined site

Mass spectrometry observed peptide

• TAVNCSSDFDACLITK (16aa)
  •    P13987    Asn-43     CD59 glycoprotein / Homo sapiens
• LFNVTPQDEQK (11aa)
  •    O75144    Asn-102     Icos ligand / Homo sapiens
• QDFNITDISLLEHR (14aa)
  •    P07911    Asn-322     Uromodulin / Homo sapiens