Hex:7 HexNAc:6 dHex:2

Taxonomy

• Homo sapiens (Human)

Protein

• 4F2 cell-surface antigen heavy chain / Homo sapiens    P08195
• Agrin / Homo sapiens    O00468
• Alpha-1-acid glycoprotein 2 / Homo sapiens    P19652
• Aminopeptidase n / Homo sapiens    P15144
• Biglycan / Homo sapiens    P21810
• CD166 antigen / Homo sapiens    Q13740
• Complement c3 / Homo sapiens    P01024
• Ectonucleoside triphosphate diphosphohydrolase 2 / Homo sapiens    Q9Y5L3
• Fibrillin-1 / Homo sapiens    P35555
• Glucosylceramidase / Homo sapiens    P04062
• Haptoglobin / Homo sapiens    P00738
• Hemopexin / Homo sapiens    P02790
• Inositol monophosphatase 3 / Homo sapiens    Q9NX62
• Integrin beta-1 / Homo sapiens    P05556
• Kininogen-1 / Homo sapiens    P01042
• L-selectin / Homo sapiens    P14151
• Leucine-rich alpha-2-glycoprotein / Homo sapiens    P02750
• Lumican / Homo sapiens    P51884
• Lysosome-associated membrane glycoprotein 1 / Homo sapiens    P11279
• Lysosome-associated membrane glycoprotein 2 / Homo sapiens    P13473
• N-acetylglucosamine-6-sulfatase / Homo sapiens    P15586
• Neural cell adhesion molecule 1 / Homo sapiens    P13591
• Polymeric immunoglobulin receptor / Homo sapiens    P01833
• UDP-glucose:glycoprotein glucosyltransferase 2 / Homo sapiens    Q9NYU1

Source

• Blood Plasma (UBERON_0001969)  
• Blood Serum (UBERON_0001977)  
• Kidney (UBERON_0002113)   BHK-21 (CVCL_1914)  
• Mammary Gland (UBERON_0001911)  
• Milk (UBERON_0001913)  

Reported structure

• N-Linked / Complex / Fuc(a1-3)[Gal(b1-4)]GlcNAc(b1-4)[Gal(b1-4)GlcNAc(b1-6)]Man(a1-3)[Fuc(a1-2)[Gal(b1-4)]GlcNAc(b1-2)[Gal(b1-4)GlcNAc(b1-6)]Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Complex / Gal(b1-4)GlcNAc(?1-?)[Gal(b1-4)GlcNAc(?1-?)]Man(a1-3)[Gal(b1-4)GlcNAc(?1-?)[Gal(b1-4)GlcNAc(?1-?)]Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc+"+ 2 x Fuc"
• N-Linked / Complex / Gal(b1-4)GlcNAc(b1-2)[Gal(b1-4)GlcNAc(b1-4)]Man(a1-3)[Gal(b1-4)GlcNAc(b1-2)[Gal(b1-4)GlcNAc(b1-6)]Man(a1-6)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc+"+ Fuc(a1-2)"
• N-Linked / Complex / Structure 3627

Composition

• Hex:7 HexNAc:6 dHex:2 (avg mass : 2664.4681 )

Disease

• Cancer, breast (DOID:1612)
• Carcinoma (DOID:305)
• Carcinoma, Hepatocellular (DOID:684)

Reference

• Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018 - Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang) / Status : Unreviewed
• Protein and Site Specificity of Fucosylation in Liver-Secreted Glycoproteins (2014 - Pompach P, Ashline DJ, Brnakova Z, Benicky J, Sanda M, Goldman R.) / Status : Reviewed
• Automated assignments of N- and O-site specific glycosylation with extensive glycan heterogeneity of glycoprotein mixtures (2013 - Strum JS1, Nwosu CC, Hua S, Kronewitter SR, Seipert RR, Bachelor RJ, An HJ, Lebrilla CB) / Status : Reviewed
• Carbohydrate structures of soluble human L-selectin recombinantly expressed in baby-hamster kidney cells. (2000 - Gohlke M, Mach U, Nuck R, Zimmermann-Kordmann M, Grunow D, Fieger C, Volz B, Tauber R, Petri T, Debus N, Reutter W) / Status : Reviewed
• Structural determination of N-linked carbohydrates by matrix-assisted laser desorption/ionization-mass spectrometry following enzymatic release within sodium dodecyl sulfate-polyacrylamide electrophoresis gels: application to species-specific glycosylation of alpha1-acid glycoprotein. (1998 - Kuster B, Hunter A, Wheeler S, Dwek R, Harvey D) / Status : Reviewed
• Comparative study of the carbohydrate moieties of rat and human plasma alpha 1-acid glycoproteins. (1981 - Yoshima H, Matsumoto A, Mizuochi T, Kawasaki T, Kobata A) / Status : Reviewed

Reported glycosite

• 4F2 cell-surface antigen heavy chain / Homo sapiens
  •        Asn-381
• Agrin / Homo sapiens
  •        Asn-250
• Alpha-1-acid glycoprotein 2 / Homo sapiens
  •        Undefined site
• Aminopeptidase n / Homo sapiens
  •        Asn-818
• Biglycan / Homo sapiens
  •        Asn-270
• CD166 antigen / Homo sapiens
  •        Asn-265
  •        Asn-306
  •        Asn-480
• Complement c3 / Homo sapiens
  •        Asn-939
• Ectonucleoside triphosphate diphosphohydrolase 2 / Homo sapiens
  •        Asn-378
• Fibrillin-1 / Homo sapiens
  •        Asn-1581
• Glucosylceramidase / Homo sapiens
  •        Asn-185
• Haptoglobin / Homo sapiens
  •        Asn-184
  •        Asn-241
• Hemopexin / Homo sapiens
  •        Asn-187
• Inositol monophosphatase 3 / Homo sapiens
  •        Asn-259
• Integrin beta-1 / Homo sapiens
  •        Asn-50
  •        Asn-212
• Kininogen-1 / Homo sapiens
  •        Asn-169
• L-selectin / Homo sapiens
  •        Undefined site
• Leucine-rich alpha-2-glycoprotein / Homo sapiens
  •        Asn-325
• Lumican / Homo sapiens
  •        Asn-127
• Lysosome-associated membrane glycoprotein 1 / Homo sapiens
  •        Asn-84
  •        Asn-261
• Lysosome-associated membrane glycoprotein 2 / Homo sapiens
  •        Asn-49
  •        Asn-275
  •        Asn-356
• N-acetylglucosamine-6-sulfatase / Homo sapiens
  •        Asn-387
• Neural cell adhesion molecule 1 / Homo sapiens
  •        Asn-347
• Polymeric immunoglobulin receptor / Homo sapiens
  •        Asn-499
• UDP-glucose:glycoprotein glucosyltransferase 2 / Homo sapiens
  •        Asn-920

Mass spectrometry observed peptide

• WQMNFTVR (8aa)
  •    P13473    Asn-49
• SCGECIQAGPNCGWCTNSTFIQEGMPTSAR (30aa)
  •    P05556    Asn-50
• SSCGKENTSDPSIVIAFGR (19aa)
  •    P11279    Asn-84
• LHINHNNLTESVGPLPK (17aa)
  •    P51884    Asn-127
• TYTYADTPDDFQIHNFSIPEEDTK (24aa)
  •    P04062    Asn-185
• SWPAVGNCSSAIR (13aa)
  •    P02790    Asn-187
• LRNPCTSEQNCTSPFSYK (18aa)
  •    P05556    Asn-212
• DPCSNVTCSFGSTCAR (16aa)
  •    O00468    Asn-250
• QVAIQTFGNQTTIIPAGGAGYK (22aa)
  •    Q9NX62    Asn-259
• IININPNK (8aa)
  •    P11279    Asn-261
• EGDNITIK (8aa)
  •    Q13740    Asn-265
• MIENGSISFIPTIR (14aa)
  •    P21810    Asn-270
• LNSSTIK (7aa)
  •    P13473    Asn-275
• NATGDYK (7aa)
  •    Q13740    Asn-306
• MFSQNDTR (8aa)
  •    P02750    Asn-325
• NISSEEK (7aa)
  •    P13591    Asn-347
• VQPFNVTQGK (10aa)
  •    P13473    Asn-356
• TSMGLPVATLQQLEAAAVNVCNQTWAQLQAR (31aa)
  •    Q9Y5L3    Asn-378
• IIIAGTNSSDIQQIISIIESNK (22aa)
  •    P08195    Asn-381
• IAGYDLNK (8aa)
  •    P15586    Asn-387
• IIISPEENVTITCTAENQIER (21aa)
  •    Q13740    Asn-480
• NATLVNEADK (10aa)
  •    P15144    Asn-818
• NATIVNEADKIR (12aa)
  •    P15144    Asn-818
• NMSDFIMK (8aa)
  •    Q9NYU1    Asn-920
• VVPEGIRMNK (10aa)
  •    P01024    Asn-939
• AWGTPCEMCPAVNTSEYK (18aa)
  •    P35555    Asn-1581