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  • Hex:3 HexNAc:3 dHex:2 NeuAc:2

Hex:3 HexNAc:3 dHex:2 NeuAc:2

SNFG, Text, Oxford
Taxonomy (1) Protein (5) Source (2) Structure (1) Composition (1) Disease (1) Site (6) Peptide (5)

    Taxonomy

  • Homo sapiens (Human)

    Protein

  • Mucin / Homo sapiens
  • Inter-alpha-trypsin inhibitor heavy chain h4 / Homo sapiens    Q14624
  • Uromodulin / Homo sapiens    P07911
  • Protein AMBP / Homo sapiens    P02760
  • Prostaglandin-h2 d-isomerase / Homo sapiens    P41222

    Source

  • Amniotic Fluid (UBERON_0000173)  
  • Urine (UBERON_0001088)  

    Reported structure

  • O-Linked / Undefined core / NeuAc(a2-3)Gal(b1-3)[Fuc(a1-4)]GlcNAc(b1-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-?)[NeuAc(a2-?)Gal(b1-?)]GalNAc

    Composition

  • Hex:3 HexNAc:3 dHex:2 NeuAc:2 (avg mass : 1988.8293 )

    Disease

  • Prostate cancer (DOID:10283)

    Reported glycosite

  • Inter-alpha-trypsin inhibitor heavy chain h4 / Homo sapiens :
    •        Ser-709
  • Mucin / Homo sapiens :
    •        Undefined site
  • Prostaglandin-h2 d-isomerase / Homo sapiens :
    •        Ser-67
    •        Ser-81
  • Protein AMBP / Homo sapiens :
    •        Thr-252
  • Uromodulin / Homo sapiens :
    •        Ser-511

    Mass spectrometry validated peptide

  • SVVAPATDGGLNLTSTFLR (19aa)
    •    P41222    Ser-67
  • SVVAPATDGGLNLTSTFLRKNQCETR (26aa)
    •    P41222    Ser-81
  • YFYNGTSMACETFQYGGCMGNGNNFVTEK (29aa)
    •    P02760    Thr-252
  • FALLMTNCYATPSSNATDPLK (21aa)
    •    P07911    Ser-511
  • LAILPASATPATSNPDPAVSR (21aa)
    •    Q14624    Ser-709
  • No image
    • O-Linked / Undefined core (avg mass : 1988.8293 )
    • Site (1)

        Reported glycosite

      • Mucin / Homo sapiens :
        •        Undefined site
  • 3 x 3 x 2 x 2 x
    • Hex:3 HexNAc:3 dHex:2 NeuAc:2 (avg mass : 1988.8293 )
    • Site (5) Suggested Structure (1)

        Suggested structure

      • O-Linked / Undefined core / NeuAc(a2-3)Gal(b1-3)[Fuc(a1-4)]GlcNAc(b1-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-?)[NeuAc(a2-?)Gal(b1-?)]GalNAc

        Reported glycosite

      • Inter-alpha-trypsin inhibitor heavy chain h4 / Homo sapiens :
        •        Ser-709
      • Prostaglandin-h2 d-isomerase / Homo sapiens :
        •        Ser-67
        •        Ser-81
      • Protein AMBP / Homo sapiens :
        •        Thr-252
      • Uromodulin / Homo sapiens :
        •        Ser-511

Composition mass

Average mass : 1988.8293 Da

Monoisotopic mass : 1987.7138 Da

References (2)

Distinct urinary glycoprotein signatures in prostate cancer patients (2018)
Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano
Pubmed : 30237853   DOI : 10.18632/oncotarget.26005
Status : Unreviewed

Structural studies on oncofetal carbohydrate antigens (Ca 19-9, Ca 50, and Ca 125) carried by O-linked sialyloligosaccharides on human amniotic mucins. (1988)
Hanisch F, Uhlenbruck G, Peter-Katalinic J, Egge H
Pubmed : 3191509  
Status : Reviewed

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