Hex:3 HexNAc:3 dHex:2 NeuAc:2

Taxonomy

• Homo sapiens (Human)

Protein

• Inter-alpha-trypsin inhibitor heavy chain h4 / Homo sapiens    Q14624
• Mucin / Homo sapiens
• Prostaglandin-h2 d-isomerase / Homo sapiens    P41222
• Protein AMBP / Homo sapiens    P02760
• Uromodulin / Homo sapiens    P07911

Source

• Amniotic Fluid (UBERON_0000173)  
• Urine (UBERON_0001088)  

Reported structure

• O-Linked / Undefined core / NeuAc(a2-3)Gal(b1-3)[Fuc(a1-4)]GlcNAc(b1-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-?)[NeuAc(a2-?)Gal(b1-?)]GalNAc

Composition

• Hex:3 HexNAc:3 dHex:2 NeuAc:2 (avg mass : 1988.8293 )

Disease

• Prostate cancer (DOID:10283)

Reference

• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed
• Structural studies on oncofetal carbohydrate antigens (Ca 19-9, Ca 50, and Ca 125) carried by O-linked sialyloligosaccharides on human amniotic mucins. (1988 - Hanisch F, Uhlenbruck G, Peter-Katalinic J, Egge H) / Status : Reviewed

Reported glycosite

• Inter-alpha-trypsin inhibitor heavy chain h4 / Homo sapiens
  •        Ser-709
• Mucin / Homo sapiens
  •        Undefined site
• Prostaglandin-h2 d-isomerase / Homo sapiens
  •        Ser-67
  •        Ser-81
• Protein AMBP / Homo sapiens
  •        Thr-252
• Uromodulin / Homo sapiens
  •        Ser-511

Mass spectrometry observed peptide

• SVVAPATDGGLNLTSTFLRKNQCETR (26aa)
  •    P41222    Ser-81
• SVVAPATDGGLNLTSTFLR (19aa)
  •    P41222    Ser-67
• YFYNGTSMACETFQYGGCMGNGNNFVTEK (29aa)
  •    P02760    Thr-252
• FALLMTNCYATPSSNATDPLK (21aa)
  •    P07911    Ser-511
• LAILPASATPATSNPDPAVSR (21aa)
  •    Q14624    Ser-709