Hex:1 HexNAc:1 NeuAc:1 NeuGc:1

Taxonomy

• Homo sapiens (Human)
• Bos taurus (Bovine)
• Mus musculus (House mouse)
• Sus scrofa (Pig)

Protein

• Inter-alpha-trypsin inhibitor heavy chain h4 / Homo sapiens    Q14624
• Lactotransferrin / Homo sapiens    P02788
• Phosphoinositide-3-kinase-interacting protein 1 / Homo sapiens    Q96FE7
• Protein yipf3 / Homo sapiens    Q9GZM5
• Chromogranin a / Bos taurus    P05059
• Coagulation factor x / Bos taurus    P00743
• Uncharacterized protein from Chromaffin Granules / Bos taurus
• Zona pellucida sperm-binding protein matrix / Mus musculus    P20239    P10761    Q62005
• Uncharacterized porcine zona pellucida glycoprotein / Sus scrofa

Source

• Blood Plasma (UBERON_0001969)  
• Urine (UBERON_0001088)  
• Zona Pellucida (UBERON_0000086)  
• Chromaffin Granules (GO_0042583)  

Reported structure

• O-Linked / Core 1 / Gal(b1-3)[NeuGc(a2-8)NeuAc(a2-6)]GalNAc
• O-Linked / Core 1 / NeuAc(a2-3)Gal(b1-3)[NeuGc(a2-6)]GalNAc
• O-Linked / Core 1 / NeuGc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GalNAc
• O-Linked / Undefined core / Gal(?1-3)GalNAc+"+ NeuGc(?2-?) + NeuAc(?2-?)"
• O-Linked / Undefined core / Gal(?1-?)GalNAc+"+ NeuAc + NeuGc"

Composition

• Hex:1 HexNAc:1 NeuAc:1 NeuGc:1 (avg mass : 981.8679 )

Disease

• Prostate cancer (DOID:10283)

Reference

• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed
• Structural analysis of murine zona pellucida glycans. Evidence for the expression of core 2-type O-glycans and the Sd(a) antigen. (2000 - Easton RL, Patankar MS, Lattanzio FA, Leaven TH, Morris HR, Clark GF, Dell A) / Status : Reviewed
• Chromogranin A from bovine adrenal medulla: molecular characterization of glycosylations, phosphorylations, and sequence heterogeneities by mass spectrometry. (1999 - Bauer S, Zhang X, Van Dongen W, Claeys M, Przybylski M) / Status : Reviewed
• Structure of the O-linked carbohydrate chains of porcine zona pellucida glycoproteins. (1994 - Hokke C, Damm J, Penninkhof B, Aitken R, Kamerling J, Vliegenthart J) / Status : Reviewed
• Glycoproteins and proteoglycans of the chromaffin granule matrix. (1982 - Kiang W-L, Krusius T, Finne J, Margolis RU, Margolis RK) / Status : Reviewed
• The structures of the carbohydrate moieties of bovine blood coagulation factor X. (1980 - Mizuochi T, Yamashita K, Fujikawa K, Titani K, Kobata A) / Status : Reviewed

Reported glycosite

• Inter-alpha-trypsin inhibitor heavy chain h4 / Homo sapiens
  •        Ser-733
• Lactotransferrin / Homo sapiens
  •        Ser-436
• Phosphoinositide-3-kinase-interacting protein 1 / Homo sapiens
  •        Ser-39
• Protein yipf3 / Homo sapiens
  •        Ser-349
• Chromogranin a / Bos taurus
  •        Ser-185
  •        Thr-249
• Coagulation factor x / Bos taurus
  •        Undefined site
• Uncharacterized protein from Chromaffin Granules / Bos taurus
  •        Undefined site
• Zona pellucida sperm-binding protein matrix / Mus musculus
  •        Undefined site
• Uncharacterized porcine zona pellucida glycoprotein / Sus scrofa
  •        Undefined site

Mass spectrometry observed peptide

• EDQTSPAPGLR (11aa)
  •    Q96FE7    Ser-39
• AVAVTLQSH (9aa)
  •    Q9GZM5    Ser-349
• CGLVPVLAENYKSQQSSDPDPNCVDR (26aa)
  •    P02788    Ser-436
• IEETTMTTQTPAPIQAPSAILPLPGQSVER (30aa)
  •    Q14624    Ser-733