Hex:5 HexNAc:5 dHex:3

Taxonomy

• Homo sapiens (Human)
• Sus scrofa (Pig)
• Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)

Protein

• Alpha-2-macroglobulin receptor-associated protein / Homo sapiens    P30533
• Biglycan / Homo sapiens    P21810
• Calumenin / Homo sapiens    O43852
• Calumenin, isoform CRA_a / Homo sapiens
• CD59 glycoprotein / Homo sapiens    P13987
• Chymotrypsin-like elastase family member 3B / Homo sapiens    P08861
• Clusterin / Homo sapiens    P10909
• Collagen alpha-2(VI) chain / Homo sapiens    P12110
• Dipeptidyl peptidase 1 / Homo sapiens    P53634
• Ectonucleoside triphosphate diphosphohydrolase 2 / Homo sapiens    Q9Y5L3
• Epidermal growth factor receptor / Homo sapiens    P00533
• Fibromodulin / Homo sapiens    Q06828
• Fibronectin / Homo sapiens    P02751
• HLA class II histocompatibility antigen, DR alpha chain / Homo sapiens    P01903
• Lumican / Homo sapiens    P51884
• Lysosome-associated membrane glycoprotein 1 / Homo sapiens    P11279
• Lysosome-associated membrane glycoprotein 2 / Homo sapiens    P13473
• Nephronectin / Homo sapiens    Q6UXI9
• Olfactomedin-like protein 3 / Homo sapiens    Q9NRN5
• Polymeric immunoglobulin receptor / Homo sapiens    P01833
• Prolactin-inducible protein / Homo sapiens    P12273
• Prosaposin / Homo sapiens    P07602
• Prostaglandin-h2 d-isomerase / Homo sapiens    P41222
• Protein AMBP / Homo sapiens    P02760
• Protein CASC4 / Homo sapiens    Q6P4E1
• Thrombospondin-1 / Homo sapiens    P07996
• Unspecified mucin / Homo sapiens
• Uromodulin / Homo sapiens    P07911
• Vitronectin / Homo sapiens    P04004
• Von willebrand factor / Homo sapiens    P04275
• WAP four-disulfide core domain protein 2 / Homo sapiens    Q14508
• Zinc-alpha-2-glycoprotein / Homo sapiens    P25311
• Mucin / Sus scrofa
• Recombinant Spike glycoprotein (FreeStyle 293-F) / Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)    P0DTC2

Source

• Blood Plasma (UBERON_0001969)  
• Mammalian Vulva (UBERON_0000997)   A-431 (CVCL_0037)  
• Mammary Gland (UBERON_0001911)  
• Pancreas (UBERON_0001264)  
• Pulmonary Mucosa  
• Stomach (UBERON_0000945)  
• Urine (UBERON_0001088)  
• FreeStyle 293-F (CVCL_D603)  

Reported structure

• N-Linked / Complex / Fuc(a1-2)[GalNAc(a1-3)]Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-2)Man(a1-3)[Gal(b1-4)GlcNAc(b1-2)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc
• N-Linked / Complex / Fuc(a1-2)[GalNAc(a1-3)]Gal(b1-?)[Fuc(a1-?)]GlcNAc(b1-2)Man(a1-3)[Gal(b1-4)GlcNAc(b1-2)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc
• N-Linked / Complex / Fuc(a1-2)Gal(b1-4)GlcNAc(b1-2)Man(a1-3)[Fuc(a1-2)Gal(b1-4)GlcNAc(b1-2)Man(a1-6)][GlcNAc(b1-4)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc
• N-Linked / Complex / Fuc(a1-2)Gal(b1-4)GlcNAc(b1-?)[GlcNAc(b1-?)]Man(a1-6)[GlcNAc(b1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc+"+ Fuc(a1-2)Gal(b1-4)"
• O-Linked / Core 2 / Fuc(a1-2)Gal(b1-4)GlcNAc(b1-6)[Fuc(a1-2)Gal(b1-4)GlcNAc(b1-3)]Gal(b1-4)GlcNAc(b1-3)Gal(b1-3)[Fuc(a1-2)Gal(b1-4)GlcNAc(b1-6)]GalNAc
• O-Linked / Core 2 / Fuc(a1-2)Gal(b1-4)GlcNAc(b1-6)[Fuc(a1-2)Gal(b1-?)GlcNAc(b1-3)]Gal(b1-?)GlcNAc(b1-3)Gal(b1-3)[Fuc(a1-2)Gal(b1-4)GlcNAc(b1-6)]GalNAc
• O-Linked / Core 9 / Fuc(a1-2)Gal(b1-?)[Fuc(a1-?)]GlcNAc(b1-?)[Fuc(a1-2)[GalNAc(a1-3)]Gal(b1-?)GlcNAc(a1-?)]Gal(b1-?)GlcNAc(b1-3)Gal(b1-3)[Gal(b1-6)]GalNAc

Composition

• Hex:5 HexNAc:5 dHex:3 (avg mass : 2283.1313 )

Disease

• Cancer, breast (DOID:1612)
• Carcinoma, Squamous cell (DOID:1749)
• COVID-19 (DOID:0080600)
• Cystic Fibrosis (DOID:1485)
• Prostate cancer (DOID:10283)

Reference

• Site-specific glycan analysis of the SARS-CoV-2 spike (2020 - Yasunori Watanabe, Joel D. Allen, Daniel Wrapp, Jason S. McLellan, Max Crispin) / Status : Unreviewed
• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed
• Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018 - Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang) / Status : Unreviewed
• Characterization of the carbohydrate chains of the secreted form of the human epidermal growth factor receptor. (2000 - Stroop C, Weber W, Gerwig G, Nimtz M, Kamerling J, Vliegenthart J) / Status : Reviewed
• Structures of sulfated oligosaccharides in human trachea mucin glycoproteins. (1993 - Sangadala S, Bhat U, Mendicino J) / Status : Reviewed
• Structures of the asparagine-linked oligosaccharide chains of human von Willebrand factor. Occurrence of blood group A, B, and H(O) structures. (1992 - Matsui T, Titani K, Mizuochi T) / Status : Reviewed
• Quantitation and structures of oligosaccharide chains in human trachea mucin glycoproteins. (1992 - Sangadala S, Bhat U, Mendicino J) / Status : Reviewed
• Carbohydrate structure of human pancreatic elastase 1. (1991 - Wendorf P, Linder D, Sziegoleit A, Geyer R) / Status : Reviewed
• Structures of the neutral oligosaccharides isolated from A-active human gastric mucin. (1984 - Slomiany A, Zdebska E, Slomiany BL) / Status : Reviewed
• Structures of the oligosaccharide chains in swine trachea mucin glycoproteins. (1984 - Chandrasekaran EV, Rana SS, Davila M, Mendicino J) / Status : Reviewed

Reported glycosite

• Alpha-2-macroglobulin receptor-associated protein / Homo sapiens
  •        Asn-268
• Biglycan / Homo sapiens
  •        Asn-270
  •        Asn-311
• Calumenin / Homo sapiens
  •        Asn-131
• Calumenin, isoform CRA_a / Homo sapiens
  •        Asn-131
• CD59 glycoprotein / Homo sapiens
  •        Thr-40
  •        Asn-43
• Chymotrypsin-like elastase family member 3B / Homo sapiens
  •        Asn-114
• Clusterin / Homo sapiens
  •        Asn-103
  •        Asn-374
• Collagen alpha-2(VI) chain / Homo sapiens
  •        Asn-785
• Dipeptidyl peptidase 1 / Homo sapiens
  •        Asn-276
• Ectonucleoside triphosphate diphosphohydrolase 2 / Homo sapiens
  •        Asn-294
• Epidermal growth factor receptor / Homo sapiens
  •        Undefined site
• Fibromodulin / Homo sapiens
  •        Asn-166
• Fibronectin / Homo sapiens
  •        Asn-430
  •        Asn-528
  •        Asn-1236
• HLA class II histocompatibility antigen, DR alpha chain / Homo sapiens
  •        Asn-143
• Lumican / Homo sapiens
  •        Asn-127
• Lysosome-associated membrane glycoprotein 1 / Homo sapiens
  •        Asn-84
• Lysosome-associated membrane glycoprotein 2 / Homo sapiens
  •        Asn-32
  •        Asn-58
• Nephronectin / Homo sapiens
  •        Asn-273
• Olfactomedin-like protein 3 / Homo sapiens
  •        Asn-248
• Polymeric immunoglobulin receptor / Homo sapiens
  •        Asn-469
• Prolactin-inducible protein / Homo sapiens
  •        Asn-105
• Prosaposin / Homo sapiens
  •        Asn-101
• Prostaglandin-h2 d-isomerase / Homo sapiens
  •        Asn-78
  •        Thr-80
• Protein AMBP / Homo sapiens
  •        Asn-250
  •        Thr-252
• Protein CASC4 / Homo sapiens
  •        Asn-150
• Thrombospondin-1 / Homo sapiens
  •        Asn-360
• Unspecified mucin / Homo sapiens
  •        Undefined site
• Uromodulin / Homo sapiens
  •        Thr-296
• Vitronectin / Homo sapiens
  •        Asn-169
• Von willebrand factor / Homo sapiens
  •        Undefined site
• WAP four-disulfide core domain protein 2 / Homo sapiens
  •        Thr-33
• Zinc-alpha-2-glycoprotein / Homo sapiens
  •        Asn-128
• Mucin / Sus scrofa
  •        Undefined site
• Recombinant Spike glycoprotein (FreeStyle 293-F) / Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
  •        Asn-74
  •        Asn-149
  •        Asn-657

Mass spectrometry observed peptide

• LELNLTDSENATCLYAK (17aa)
  •    P13473    Asn-32
• TGVCPELQADQNCTQECVSDSECADNLK (28aa)
  •    Q14508    Thr-33
• TAVNCSSDFDACLITK (16aa)
  •    P13987    Thr-40
• TAVNCSSDFDACLITK (16aa)
  •    P13987    Asn-43
• YETTNK (6aa)
  •    P13473    Asn-58
• SVVAPATDGGLNLTSTFLRK (20aa)
  •    P41222    Asn-78
• SVVAPATDGGLNLTSTFLR (19aa)
  •    P41222    Thr-80
• HAIHVSGTNGTKRF (14aa)
  •    P0DTC2    Asn-74
• SSCGKENTSDPSIVIAFGR (19aa)
  •    P11279    Asn-84
• ENTSDPSIVIAFGR (14aa)
  •    P11279    Asn-84
• TCDWIPKPNMSASCK (15aa)
  •    P07602    Asn-101
• ELPGVCNETMMALWEECKPCLK (22aa)
  •    P10909    Asn-103
• TFYWDFYTNR (10aa)
  •    P12273    Asn-105
• LHINHNNLTESVGPLPK (17aa)
  •    P51884    Asn-127
• KLHINHNNLTESVGPLPK (18aa)
  •    P51884    Asn-127
• FGCEIENNR (9aa)
  •    P25311    Asn-128
• NVTYGTYIDDPDPDDGFNYK (20aa)
• NVTYGTYIDDPDPDDGFNYK (20aa)
  •    O43852    Asn-131
• NATYGYVIDDPDPDDGFNYK (20aa)
  •    O43852    Asn-131
• TPPVVNVTW (9aa)
  •    P01903    Asn-143
• YHKNNKSWMESEF (13aa)
  •    P0DTC2    Asn-149
• NNTYLVK (7aa)
  •    Q6P4E1    Asn-150
• IYIDHNNITR (10aa)
  •    Q06828    Asn-166
• NGSLFAFR (8aa)
  •    P04004    Asn-169
• FHLANR (6aa)
  •    Q9NRN5    Asn-248
• YFYNGTSMACETFQYGGCMGNGNNFVTEK (29aa)
  •    P02760    Asn-250
• YFYNGTSMACETFQYGGCMGNGNNFVTEK (29aa)
  •    P02760    Thr-252
• VIDLWDLAQSANLTDK (16aa)
  •    P30533    Asn-268
• MIENGSISFIPTIR (14aa)
  •    P21810    Asn-270
• GNGTILK (7aa)
  •    Q6UXI9    Asn-273
• IITNNSQTPIISPQEVVSCSQYAQGCEGGFPYIIAGK (37aa)
  •    P53634    Asn-276
• ACAGGYYVYNLTAPPECHLAYCTDPSSVEGTCEECSIDEDCKSNNGRWHCQCK (53aa)
  •    P07911    Thr-296
• GFSTQVLLGDVYQSPCTMAQRPQNFNSSAR (30aa)
  •    Q9Y5L3    Asn-294
• IIQVVYIHSNNITK (14aa)
  •    P21810    Asn-311
• VSCPIMPCSNATVPDGECCPR (21aa)
  •    P07996    Asn-360
• KVSCPIMPCSNATVPDGECCPR (22aa)
  •    P07996    Asn-360
• IANITQGEDQYYIR (14aa)
  •    P10909    Asn-374
• NYTDCTSEGR (10aa)
  •    P02751    Asn-430
• VPGNVTAVIGETIK (14aa)
  •    P01833    Asn-469
• DQCIVDDITYNVNDTFHK (18aa)
  •    P02751    Asn-528
• NNSYECDIPI (10aa)
  •    P0DTC2    Asn-657
• NMTLFSDLVAEK (12aa)
  •    P12110    Asn-785
• ITTTPTNGQQGNSIEEVVHADQSSCTFDNISPGIEYNVSVYTVK (44aa)
  •    P02751    Asn-1236