Hex:3 HexNAc:3 dHex:1 NeuAc:2

Taxonomy

• Homo sapiens (Human)

Protein

• Coagulation factor V / Homo sapiens    P12259
• Matrix metalloproteinase-9 / Homo sapiens    P14780
• Prostaglandin-h2 d-isomerase / Homo sapiens    P41222
• Protein YIPF3 / Homo sapiens    Q9GZM5
• Uncharacterized protein / Homo sapiens    
• Unspecified mucin / Homo sapiens    
• Uromodulin / Homo sapiens    P07911

Source

• Amniotic Fluid (UBERON_0000173)  
• Blood Plasma (UBERON_0001969)  
• Urine (UBERON_0001088)  
• LS174T (CVCL_1384)  
• LS180 (CVCL_0397)  
• SW1116 (CVCL_0544)  
• SW948 (CVCL_0632)  
• T84 (CVCL_0555)  
• Granulocyte (CL_0000094)  
• Neutrophil (CL_0000775)  

Reported structure

• O-Linked / Core 1 / Structure 11101
• O-Linked / Core 2 / NeuAc(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-3)]GalNAc
• O-Linked / Core 2 / NeuAc(a2-6)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-?)Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-3)]GalNAc
• O-Linked / Core 2 / Structure 9363
• O-Linked / Core 2 / Structure 11087
• O-Linked / Core 2 / Structure 11091
• O-Linked / Core 2 / Structure 11185
• O-Linked / Undefined core / NeuAc(a2-3)Gal(b1-3)[Fuc(a1-4)]GlcNAc(b1-3)Gal(b1-4)GlcNAc(b1-?)[NeuAc(a2-?)Gal(b1-?)]GalNAc

Composition

• Hex:3 HexNAc:3 dHex:1 NeuAc:2 (avg mass : 1842.6863 )

Disease

• Colon adenocarcinoma (DOID:234)
• Prostate cancer (DOID:10283)

Reference

• Colorectal cancer cell lines show striking diversity of their O-glycome reflecting the cellular differentiation phenotype (2021 - Katarina Madunić, Tao Zhang, Oleg A Mayboroda, Stephanie Holst, Kathrin Stavenhagen, Chunsheng Jin, Niclas G Karlsson, Guinevere S M Lageveen-Kammeijer, Manfred Wuhrer) / Status : Reviewed
• Comprehensive N- and O-glycosylation mapping of human coagulation factor V. (2020 - Ma C, Liu D, Li D, Zhang J, Xu XQ, Zhu H, Wan XF, Miao CH, Konkle BA, Onigman P, Xiao W, Li L) / Status : Reviewed
• Extended Sialylated O-Glycan Repertoire of Human Urinary Glycoproteins Discovered and Characterized Using Electron-Transfer/Higher-Energy Collision Dissociation (2019 - Zsuzsanna Darula, Ádám Pap, Katalin F. Medzihradszky) / Status : Reviewed
• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed
• O-glycan analysis of natural human neutrophil gelatinase B using a combination of normal phase-HPLC and online tandem mass spectrometry: implications for the domain organization of the enzyme. (2000 - Mattu T, Royle L, Langridge J, Wormald M, Van den Steen P, Van Damme J, Opdenakker G, Harvey D, Dwek R, Rudd P) / Status : Reviewed
• Structural studies on oncofetal carbohydrate antigens (Ca 19-9, Ca 50, and Ca 125) carried by O-linked sialyloligosaccharides on human amniotic mucins. (1988 - Hanisch F, Uhlenbruck G, Peter-Katalinic J, Egge H) / Status : Reviewed
• Structures of O-linked oligosaccharides isolated from normal granulocytes, chronic myelogenous leukemia cells, and acute myelogenous leukemia cells. (1986 - Fukuda M, Carlsson S, Klock J, Dell A) / Status : Reviewed

Reported glycosite

• Coagulation factor V / Homo sapiens
  •        Ser-985
• Matrix metalloproteinase-9 / Homo sapiens
  •        Undefined site
• Prostaglandin-h2 d-isomerase / Homo sapiens
  •        Ser-67
• Protein YIPF3 / Homo sapiens
  •        Thr-346
• Uncharacterized protein / Homo sapiens
  •        Undefined site
• Unspecified mucin / Homo sapiens
  •        Undefined site
• Uromodulin / Homo sapiens
  •        Thr-504

Mass spectrometry observed peptide

• SVVAPATDGGLNLTSTFLRK (20aa)
  •    P41222    Ser-67     Prostaglandin-h2 d-isomerase / Homo sapiens
• AVAVTLQSH (9aa)
  •    Q9GZM5    Thr-346     Protein YIPF3 / Homo sapiens
• FALLMTNCYATPSSNATDPLKYFIIQDR (28aa)
  •    P07911    Thr-504     Uromodulin / Homo sapiens