Hex:5 HexNAc:6 dHex:1 NeuAc:2

Taxonomy

• Homo sapiens (Human)
• Mus musculus (House mouse)
• Rattus norvegicus (Norway rat)

Protein

• Inter-alpha-trypsin inhibitor heavy chain h4 / Homo sapiens    Q14624
• Prostaglandin-h2 d-isomerase / Homo sapiens    P41222
• Thrombopoietin / Homo sapiens    P40225
• Dystroglycan / Mus musculus    Q62165
• Glutamate receptor 1 / Mus musculus    P23818
• Glutamate receptor 2 / Mus musculus    P23819
• Myelin-oligodendrocyte glycoprotein / Mus musculus    Q61885
• Low density lipoprotein receptor-related protein 2 / Rattus norvegicus    P98158
• Neuroligin 1 / Rattus norvegicus    Q62765

Source

• Brain (UBERON_0000955)  
• Kidney (UBERON_0002113)   BHK570 (CVCL_6370)   Fibroblast (CL_0000057)  
• Kidney (UBERON_0002113)   HEK293 (CVCL_0045)  
• Kidney (UBERON_0002113)   HEK293-EBNA (CVCL_6974)  
• Urine (UBERON_0001088)  
• Microsome (GO_0005792)  

Reported structure

• N-Linked / Complex / Structure 439
• N-Linked / Undefined core / Gal(b1-4)GlcNAc(b1-?)[GlcNAc(b1-?)]Man(a1-?)[GlcNAc(b1-?)Man(a1-?)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc+"+ GalNac(b1-4) + NeuAc(a2-3) + NeuAc(a2-3)Gal(b1-4)"
• N-Linked / Complex / GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)GlcNAc(b1-2)Man(a1-3)[GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)GlcNAc(b1-2)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc
• N-Linked / Complex / HexNAc(?1-?)Man(a1-?)[HexNAc(?1-?)[HexNAc(?1-?)]Man(a1-?)]Man(b1-4)GlcNAc(b1-4)[Fuc(?1-?)]GlcNAc+"+ (2 x Hex) + HexNAc + (2 x NeuAc)"

Composition

• Hex:5 HexNAc:6 dHex:1 NeuAc:2 (avg mass : 2776.5561 )

Disease

• Prostate cancer (DOID:10283)

Reference

• Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis (2019 - Nicholas M. Riley, Alexander S. Hebert, Michael S. Westphall & Joshua J. Coon ) / Status : Unreviewed
• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed
• Site-specific glycan microheterogeneity of inter-alpha-trypsin inhibitor heavy chain H4 (2014 - Chandler KB, Brnakova Z, Sanda M, Wang S, Stalnaker SH, Bridger R, Zhao P, Wells L, Edwards NJ, Goldman R.) / Status : Reviewed
• Structural characterization of recombinant soluble rat neuroligin 1: mapping of secondary structure and glycosylation by mass spectrometry. (2004 - Hoffman RC, Jennings LL, Tsigelny I, Comoletti D, Flynn RE, Sudhof TC, Taylor P) / Status : Reviewed
• Characterization of the N-linked oligosaccharides of megalin (gp330) from rat kidney. (2000 - Morelle W, Haslam S, Ziak M, Roth J, Morris H, Dell A) / Status : Reviewed
• Peptide, disulfide, and glycosylation mapping of recombinant human thrombopoietin from ser1 to Arg246. (1996 - Hoffman RC, Andersen H, Walker K, Krakover JD, Patel S, Stamm MR, Osborn SG) / Status : Reviewed

Reported glycosite

• Inter-alpha-trypsin inhibitor heavy chain h4 / Homo sapiens
  •        Asn-577
• Prostaglandin-h2 d-isomerase / Homo sapiens
  •        Asn-78
• Thrombopoietin / Homo sapiens
  •        Undefined site
• Dystroglycan / Mus musculus
  •        Asn-647
• Glutamate receptor 1 / Mus musculus
  •        Asn-257
• Glutamate receptor 2 / Mus musculus
  •        Asn-406
• Myelin-oligodendrocyte glycoprotein / Mus musculus
  •        Asn-59
• Low density lipoprotein receptor-related protein 2 / Rattus norvegicus
  •        Undefined site
• Neuroligin 1 / Rattus norvegicus
  •        Undefined site

Mass spectrometry observed peptide

• NATGMEVGWYR (11aa)
  •    Q61885    Asn-59
• SVVAPATDGGLNLTSTFLR (19aa)
  •    P41222    Asn-78
• ESGANVTGFQLVNYTDTIPAR (21aa)
  •    P23818    Asn-257
• MVVTLTELPSGNDTSGLENK (20aa)
  •    P23819    Asn-406
• LAFAFGDRNCSSITLQNITR (20aa)
  •    Q62165    Asn-647