Hex:6 HexNAc:5 NeuAc:2 NeuGc:1

Taxonomy

• Homo sapiens (Human)
• Bos taurus (Bovine)
• Ovis aries (Sheep)

Protein

• Alpha-1-acid glycoprotein 1 / Homo sapiens    P02763
• Carboxypeptidase b2 / Homo sapiens    Q96IY4
• CD59 glycoprotein / Homo sapiens    P13987
• Alpha-1-acid glycoprotein / Bos taurus    Q3SZR3
• Alpha-1-acid glycoprotein / Ovis aries    W5P7S6

Source

• Blood Serum (UBERON_0001977)  
• Urine (UBERON_0001088)  

Reported structure

• N-Linked / Complex / Gal(b1-4)GlcNAc(?1-?)Man(a1-3)[Gal(b1-4)GlcNAc(?1-?)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc+"+ Gal(b1-4)GlcNAc(?1-?) + 2 x NeuAc(a2-?) + NeuGc(a2-?)"

Composition

• Hex:6 HexNAc:5 NeuAc:2 NeuGc:1 (avg mass : 2896.6178 )

Disease

• Prostate cancer (DOID:10283)

Reference

• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed
• Structural determination of N-linked carbohydrates by matrix-assisted laser desorption/ionization-mass spectrometry following enzymatic release within sodium dodecyl sulfate-polyacrylamide electrophoresis gels: application to species-specific glycosylation of alpha1-acid glycoprotein. (1998 - Kuster B, Hunter A, Wheeler S, Dwek R, Harvey D) / Status : Reviewed

Reported glycosite

• Alpha-1-acid glycoprotein 1 / Homo sapiens
  •        Asn-72
• Carboxypeptidase b2 / Homo sapiens
  •        Asn-73
• CD59 glycoprotein / Homo sapiens
  •        Asn-43
• Alpha-1-acid glycoprotein / Bos taurus
  •        Undefined site
• Alpha-1-acid glycoprotein / Ovis aries
  •        Undefined site

Mass spectrometry observed peptide

• TAVNCSSDFDACLITK (16aa)
  •    P13987    Asn-43     CD59 glycoprotein / Homo sapiens
• SVQEIQATFFYFTPNK (16aa)
  •    P02763    Asn-72     Alpha-1-acid glycoprotein 1 / Homo sapiens
• QVHFFVNASDVDNVK (15aa)
  •    Q96IY4    Asn-73     Carboxypeptidase b2 / Homo sapiens