Hex:6 HexNAc:6 dHex:2

Taxonomy

• Homo sapiens (Human)
• Mesocricetus auratus (Golden hamster)
• Mus musculus (House mouse)

Protein

• CD59 glycoprotein / Homo sapiens    P13987
• Epidermal growth factor receptor / Homo sapiens    P00533
• Erythropoietin / Homo sapiens    P01588
• Uromodulin / Homo sapiens    P07911
• Major prion protein / Mesocricetus auratus    P04273
• Isoform 2 of Voltage-dependent calcium channel subunit alpha-2/delta-2 / Mus musculus    Q6PHS9-2

Source

• Brain (UBERON_0000955)  
• Mammalian Vulva (UBERON_0000997)   A-431 (CVCL_0037)  
• Urine (UBERON_0001088)  
• RPMI-1788 (CVCL_2710)   B-Lymphocyte (CL_0000236)  

Reported structure

• N-Linked / Complex / Fuc(a1-2)[GalNAc(a1-3)]Gal(b1-4)GlcNAc(b1-2)Man(a1-3)[Gal(b1-4)GlcNAc(b1-2)[Gal(b1-4)GlcNAc(b1-6)]Man(a1-6)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc
• N-Linked / Complex / Fuc(a1-2)[GalNAc(a1-3)]Gal(b1-4)GlcNAc(b1-?)[Gal(b1-4)GlcNAc(b1-?)]Man(a1-6)[Gal(b1-4)GlcNAc(b1-2)Man(a1-3)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc
• N-Linked / Complex / Gal(?1-?)GlcNAc(?1-?)[Gal(?1-?)GlcNAc(?1-?)]Man(a1-?)[Gal(?1-?)GlcNAc(?1-?)Man(a1-?)][GlcNAc(?1-4)]Man(b1-4)GlcNAc(b1-4)[Fuc(?1-6)]GlcNAc+"+ Fuc"
• N-Linked / Complex / Gal(b1-4)GlcNAc(b1-2)[Gal(b1-4)GlcNAc(b1-4)]Man(a1-3)[Fuc(a1-3)[Gal(b1-4)]GlcNAc(b1-2)Man(a1-6)][GlcNAc(b1-4)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc

Composition

• Hex:6 HexNAc:6 dHex:2 (avg mass : 2502.3257 )

Disease

• Carcinoma, Squamous cell (DOID:1749)
• Prostate cancer (DOID:10283)
• Scrapie (DOID:5434)

Reference

• Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis (2019 - Nicholas M. Riley, Alexander S. Hebert, Michael S. Westphall & Joshua J. Coon ) / Status : Unreviewed
• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed
• Unusual N-glycosylation of a recombinant human erythropoietin expressed in a human lymphoblastoid cell line does not alter its biological properties. (2000 - Cointe D, Bliard R, Jorieux S, Leroy Y, Glacet A, Verbert A, Bourel D, Chirat F) / Status : Reviewed
• Characterization of the carbohydrate chains of the secreted form of the human epidermal growth factor receptor. (2000 - Stroop C, Weber W, Gerwig G, Nimtz M, Kamerling J, Vliegenthart J) / Status : Reviewed
• Diversity of oligosaccharide structures linked to asparagines of the scrapie prion protein. (1989 - Endo T, Groth D, Prusiner SB, Kobata A) / Status : Reviewed

Reported glycosite

• CD59 glycoprotein / Homo sapiens
  •        Asn-43
• Epidermal growth factor receptor / Homo sapiens
  •        Undefined site
• Erythropoietin / Homo sapiens
  •        Asn-51
• Uromodulin / Homo sapiens
  •        Asn-513
• Major prion protein / Mesocricetus auratus
  •        Undefined site
• Isoform 2 of Voltage-dependent calcium channel subunit alpha-2/delta-2 / Mus musculus
  •        Asn-627

Mass spectrometry observed peptide

• TAVNCSSDFDACLITK (16aa)
  •    P13987    Asn-43
• FALLMTNCYATPSSNATDPLK (21aa)
  •    P07911    Asn-513
• NYTWVPIR (8aa)
  •    Q6PHS9-2    Asn-627