Hex:3 HexNAc:4 Su:1

Taxonomy

• Homo sapiens (Human)
• Bos taurus (Bovine)
• Ovis aries (Sheep)

Protein

• Glycoprotein hormones alpha chain - choriogonadotropin / Homo sapiens    P01215
• Lutropin beta chain / Homo sapiens    P01229
• Thyrotropin-aplha and beta chains / Bos taurus    P01217    P01223
• Glycoprotein hormones alpha chain - lutropin / Ovis aries    P01218
• Lutropin beta chain / Ovis aries    P01231

Source

• Adenohypophysis (UBERON_0002196)  
• Pituitary Gland (UBERON_0000007)  
• C10 (CVCL_5245)  
• Co115 (CVCL_D102)  
• HCT 15 (CVCL_0292)  
• LS180 (CVCL_0397)  
• LS411N (CVCL_1385)  
• SW1116 (CVCL_0544)  
• SW1463 (CVCL_1718)  
• T84 (CVCL_0555)  

Reported structure

• N-Linked / Complex / HSO3(-4)GalNAc(?1-?)GlcNAc(?1-?)Man(a1-?)[Man(a1-?)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Complex / HSO3(-4)GalNAc(b1-4)GlcNAc(b1-2)Man(a1-3)[Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• O-Linked / Core 4 / Structure 11099

Composition

• Hex:3 HexNAc:4 Su:1 (avg mass : 1397.2867 )

Disease

• Cecum adenocarcinoma (DOID:3039)
• Colon adenocarcinoma (DOID:234)
• Rectal adenocarcinoma (DOID:1996)

Reference

• Colorectal cancer cell lines show striking diversity of their O-glycome reflecting the cellular differentiation phenotype (2021 - Katarina Madunić, Tao Zhang, Oleg A Mayboroda, Stephanie Holst, Kathrin Stavenhagen, Chunsheng Jin, Niclas G Karlsson, Guinevere S M Lageveen-Kammeijer, Manfred Wuhrer) / Status : Reviewed
• Extension of the in-gel release method for structural analysis of neutral and sialylated N-linked glycans to the analysis of sulfated glycans: application to the glycans from bovine thyroid-stimulating hormone (2001 - Wheeler, Harvey) / Status : Reviewed
• NMR investigations of the N-linked oligosaccharides at individual glycosylation sites of human lutropin. (1991 - Weisshaar G, Hiyama J, Renwick A, Nimtz M) / Status : Reviewed
• Site-specific N-glycosylation of ovine lutropin. Structural analysis by one- and two-dimensional 1H-NMR spectroscopy. (1990 - Weisshaar G, Hiyama J, Renwick A) / Status : Reviewed

Reported glycosite

• Glycoprotein hormones alpha chain - choriogonadotropin / Homo sapiens
  •        Asn-76
  •        Asn-102
• Lutropin beta chain / Homo sapiens
  •        Asn-50
• Thyrotropin-aplha and beta chains / Bos taurus
  •        Undefined site
• Glycoprotein hormones alpha chain - lutropin / Ovis aries
  •        Asn-80
  •        Asn-106
• Lutropin beta chain / Ovis aries
  •        Asn-33

Mass spectrometry observed peptide