Hex:4 HexNAc:4 dHex:3 NeuAc:1

Taxonomy

• Homo sapiens (Human)

Protein

• Immunoglobulin alpha (secretory) / Homo sapiens    P01876    P01877
• P-selectin glycoprotein ligand (psgl-1) / Homo sapiens    Q14242
• Plasma protease c1 inhibitor / Homo sapiens    P05155
• Prostaglandin-h2 d-isomerase / Homo sapiens    P41222
• Uncharacterized protein from Granulocyte / Homo sapiens

Source

• Milk (UBERON_0001913)  
• Urine (UBERON_0001088)  
• HL-60 (CVCL_0002)   Leukocyte (CL_0000738)  
• Granulocyte (CL_0000094)  

Reported structure

• O-Linked / Core 2 / Fuc(a1-2)Gal(b1-3)[Fuc(a1-4)]GlcNAc(b1-3)[Fuc(a1-3)[Gal(b1-4)]GlcNAc(b1-6)]Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-3)]GalNAc
• O-Linked / Core 2 / Fuc(a1-2)Gal(b1-3)[Fuc(a1-4)]GlcNAc(b1-3)[Gal(b1-4)GlcNAc(b1-6)]Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-3)]GalNAc
• O-Linked / Core 2 / Fuc(a1-3)[Gal(b1-4)]GlcNAc(b1-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-3)]GalNAc
• O-Linked / Core 2 / NeuAc(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-6)[Gal(b1-3)]GalNAc

Composition

• Hex:4 HexNAc:4 dHex:3 NeuAc:1 (avg mass : 2209.0518 )

Disease

• Leukemia, Promyelocytic (DOID:0060318)
• Prostate cancer (DOID:10283)

Reference

• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed
• Structures of the O-glycans on P-selectin glycoprotein ligand-1 from HL-60 cells. (1996 - Wilkins P, McEver R, Cummings R) / Status : Reviewed
• Primary structure of twenty three neutral and monosialylated oligosaccharides O-glycosidically linked to the human secretory immunoglobulin A hinge region determined by a combination of permethylation analysis and 400-MHz 1H-NMR spectroscopy. (1989 - Pierce-Cretel A, Decottignies J, Wieruszeski J, Strecker G, Montreuil J, Spik G) / Status : Reviewed
• Structures of O-linked oligosaccharides isolated from normal granulocytes, chronic myelogenous leukemia cells, and acute myelogenous leukemia cells. (1986 - Fukuda M, Carlsson S, Klock J, Dell A) / Status : Reviewed

Reported glycosite

• Immunoglobulin alpha (secretory) / Homo sapiens
  •        Undefined site
• P-selectin glycoprotein ligand (psgl-1) / Homo sapiens
  •        Undefined site
• Plasma protease c1 inhibitor / Homo sapiens
  •        Ser-36
• Prostaglandin-h2 d-isomerase / Homo sapiens
  •        Ser-67
• Uncharacterized protein from Granulocyte / Homo sapiens
  •        Undefined site

Mass spectrometry observed peptide

• ASSNPNATSSSSQDPESLQDRGEGK (25aa)
  •    P05155    Ser-36
• ASSNPNATSSSSQDPESLQDR (21aa)
  •    P05155    Ser-36
• SVVAPATDGGLNLTSTFLR (19aa)
  •    P41222    Ser-67