Hex:7 HexNAc:6 dHex:2 NeuAc:4

Taxonomy

• Homo sapiens (Human)

Protein

• Adhesion G protein-coupled receptor F5 / Homo sapiens    Q8IZF2
• Alpha-1-acid glycoprotein 1 / Homo sapiens    P02763
• Alpha-1-acid glycoprotein 2 / Homo sapiens    P19652
• Alpha-1-antichymotrypsin / Homo sapiens    P01011
• Alpha-1-antitrypsin / Homo sapiens    P01009
• Apolipoprotein B-100 / Homo sapiens    P04114
• Apolipoprotein D / Homo sapiens    P05090
• Epidermal growth factor receptor / Homo sapiens    P00533
• Gamma-glutamyltranspeptidase 1 / Homo sapiens    P19440
• Histidine-rich glycoprotein / Homo sapiens    P04196
• Laminin subunit beta-1 / Homo sapiens    P07942
• Receptor-type tyrosine-protein phosphatase mu / Homo sapiens    P28827

Source

• Blood Serum (UBERON_0001977)  
• Mammalian Vulva (UBERON_0000997)   A-431 (CVCL_0037)  

Reported structure

• N-Linked / Complex / Gal(b1-4)GlcNAc(?1-?)[Gal(b1-4)GlcNAc(?1-?)]Man(a1-3)[Gal(b1-4)GlcNAc(?1-?)[Gal(b1-4)GlcNAc(?1-?)]Man(a1-6)]Man(b1-4)GlcNAc(b1-4)GlcNAc+"+ 2 x Fuc + 4 x NeuAc(a2-?)"
• N-Linked / Complex / NeuAc(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-4)[NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-2)]Man(a1-3)[NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-2)[NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-6)]Man(a1-6)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc
• N-Linked / Complex / NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-2)[NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-4)]Man(a1-3)[NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-2)[NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-6)]Man(a1-6)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc+"+ Fuc(a1-3)"
• N-Linked / Complex / Structure 10719

Composition

• Hex:7 HexNAc:6 dHex:2 NeuAc:4 (avg mass : 3829.4997 )

Disease

• Carcinoma, Squamous cell (DOID:1749)
• Control/Healthy
• Familial hepatic adenoma (DOID:111366)
• Prostate cancer (DOID:10283)

Reference

• Aberrant sialylation in a patient with a HNF1α variant and liver adenomatosis (2021 - Luisa Sturiale, Marie-Cécile Nassogne, Angelo Palmigiano, Angela Messina, Immacolata Speciale, Rosangela Artuso, Gaetano Bertino, Nicole Revencu, Xavier Stephénne, Cristina De Castro, Gert Matthijs, Rita Barone, Jaak Jaeken, Domenico Garozzo) / Status : Reviewed
• Large-scale intact glycopeptide identification by Mascot database search (2018 - Ravi Chand Bollineni, Christian Jeffrey Koehler, Randi Elin Gislefoss, Jan Haug Anonsen, Bernd Thiede) / Status : Unreviewed
• Characterization of the carbohydrate chains of the secreted form of the human epidermal growth factor receptor. (2000 - Stroop C, Weber W, Gerwig G, Nimtz M, Kamerling J, Vliegenthart J) / Status : Reviewed
• Structural determination of N-linked carbohydrates by matrix-assisted laser desorption/ionization-mass spectrometry following enzymatic release within sodium dodecyl sulfate-polyacrylamide electrophoresis gels: application to species-specific glycosylation of alpha1-acid glycoprotein. (1998 - Kuster B, Hunter A, Wheeler S, Dwek R, Harvey D) / Status : Reviewed

Reported glycosite

• Adhesion G protein-coupled receptor F5 / Homo sapiens
  •        Asn-315
• Alpha-1-acid glycoprotein 1 / Homo sapiens
  •        Undefined site
  •        Asn-93
• Alpha-1-acid glycoprotein 2 / Homo sapiens
  •        Undefined site
• Alpha-1-antichymotrypsin / Homo sapiens
  •        Asn-106
  •        Asn-271
• Alpha-1-antitrypsin / Homo sapiens
  •        Undefined site
• Apolipoprotein B-100 / Homo sapiens
  •        Asn-3411
• Apolipoprotein D / Homo sapiens
  •        Asn-98
• Epidermal growth factor receptor / Homo sapiens
  •        Undefined site
• Gamma-glutamyltranspeptidase 1 / Homo sapiens
  •        Asn-120
• Histidine-rich glycoprotein / Homo sapiens
  •        Asn-344
• Laminin subunit beta-1 / Homo sapiens
  •        Asn-1542
• Receptor-type tyrosine-protein phosphatase mu / Homo sapiens
  •        Asn-131

Mass spectrometry observed peptide

• QDQCIYNTTYLNVQR (15aa)
  •    P02763    Asn-93     Alpha-1-acid glycoprotein 1 / Homo sapiens
• ADGTVNQIEGEATPVNLTEPAK (22aa)
  •    P05090    Asn-98     Apolipoprotein D / Homo sapiens
• FNLTETSEAEIHQSFQHLLR (20aa)
  •    P01011    Asn-106     Alpha-1-antichymotrypsin / Homo sapiens
• LAFATMFNSSEQSQK (15aa)
  •    P19440    Asn-120     Gamma-glutamyltranspeptidase 1 / Homo sapiens
• VNNGPLGNPIWNISGDPTR (19aa)
  •    P28827    Asn-131     Receptor-type tyrosine-protein phosphatase mu / Homo sapiens
• YTGNASALFILPDQDK (16aa)
  •    P01011    Asn-271     Alpha-1-antichymotrypsin / Homo sapiens
• YEEQQLEIQNSSR (13aa)
  •    Q8IZF2    Asn-315     Adhesion G protein-coupled receptor F5 / Homo sapiens
• HSHNNNSSDLHPHK (14aa)
  •    P04196    Asn-344     Histidine-rich glycoprotein / Homo sapiens
• MEMPSTPQQLQNLTEDIR (18aa)
  •    P07942    Asn-1542     Laminin subunit beta-1 / Homo sapiens
• FVEGSHNSTVSLTTK (15aa)
  •    P04114    Asn-3411     Apolipoprotein B-100 / Homo sapiens