Hex:6 HexNAc:7 dHex:1

Taxonomy

• Homo sapiens (Human)
• Bos taurus (Bovine)
• Sus scrofa (Pig)

Protein

• Erythropoietin / Homo sapiens    P01588
• Glandular kallikrein 1 / Homo sapiens    P06870
• Inter-alpha-trypsin inhibitor heavy chain H3 / Homo sapiens    Q06033
• Lysosome-associated membrane glycoprotein 2 / Homo sapiens    P13473
• Uromodulin / Homo sapiens    P07911
• Platelet glycoprotein IV / Bos taurus    P26201
• Uncharacterized protein from Milk Fat Globule Membrane / Bos taurus
• Uncharacterized porcine zona pellucida glycoprotein / Sus scrofa

Source

• Mammary Gland (UBERON_0001911)  
• Milk (UBERON_0001913)   Plasma Membrane (GO_0005886)  
• Urine (UBERON_0001088)  
• Zona Pellucida (UBERON_0000086)  
• RPMI-1788 (CVCL_2710)   B-Lymphocyte (CL_0000236)  

Reported structure

• N-Linked / Complex / Gal(?1-?)GlcNAc(?1-?)[Gal(?1-?)GlcNAc(?1-?)]Man(a1-?)[Gal(?1-?)GlcNAc(?1-?)Man(a1-?)][GlcNAc(?1-4)]Man(b1-4)GlcNAc(b1-4)[Fuc(?1-6)]GlcNAc+"+ GlcNAc"
• N-Linked / Complex / Gal(b1-4)GlcNAc(b1-2)[Gal(b1-4)GlcNAc(b1-6)]Man(a1-6)[Gal(b1-4)GlcNAc(b1-4)[GalNAc(b1-4)GlcNAc(b1-2)]Man(a1-3)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc
• N-Linked / Complex / GlcNAc(b1-2)[GlcNAc(b1-4)]Man(a1-?)[GlcNAc(b1-2)[GlcNAc(b1-6)]Man(a1-?)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc+"+ 3 x Gal(b1-4) + GalNAc(b1-4)"
• N-Linked / Complex / GlcNAc(b1-3)Gal(b1-4)GlcNAc(b1-?)[GlcNAc(b1-?)]Man(a1-6)[Gal(b1-4)GlcNAc(b1-2)[Gal(b1-4)GlcNAc(b1-4)]Man(a1-3)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc

Composition

• Hex:6 HexNAc:7 dHex:1 (avg mass : 2559.3777 )

Disease

• Cancer, breast (DOID:1612)
• Prostate cancer (DOID:10283)

Reference

• Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018 - Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang) / Status : Unreviewed
• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed
• Unusual N-glycosylation of a recombinant human erythropoietin expressed in a human lymphoblastoid cell line does not alter its biological properties. (2000 - Cointe D, Bliard R, Jorieux S, Leroy Y, Glacet A, Verbert A, Bourel D, Chirat F) / Status : Reviewed
• Structural elucidation of a variety of GalNAc-containing N-linked oligosaccharides from human urinary kallidinogenase. (1993 - Tomiya N, Awaya J, Kurono M, Hanzawa H, Shimada I, Arata Y, Yoshida T, Takahashi N) / Status : Reviewed
• Most bovine milk fat globule membrane glycoproteins contain asparagine-linked sugar chains with GalNAc beta 1-->4GlcNAc groups. (1993 - Sato T, Furukawa K, Greenwalt D, Kobata A) / Status : Reviewed
• Structural study of the sugar chains of CD36 purified from bovine mammary epithelial cells: occurrence of novel hybrid-type sugar chains containing the Neu5Ac alpha 2-->6GalNAc beta 1-->4GlcNAc and the Man alpha 1-->2Man alpha 1-->3Man alpha 1-->6Man groups. (1993 - Nakata N, Furukawa K, Greenwalt D, Sato T, Kobata A) / Status : Reviewed
• Neutral oligosaccharide structures linked to asparagines of porcine zona pellucida glycoproteins. (1991 - Mori E, Takasaki S, Hedrick J, Wardrip N, Mori T, Kobata A) / Status : Reviewed

Reported glycosite

• Erythropoietin / Homo sapiens
  •        Asn-51
• Glandular kallikrein 1 / Homo sapiens
  •        Undefined site
• Inter-alpha-trypsin inhibitor heavy chain H3 / Homo sapiens
  •        Asn-91
• Lysosome-associated membrane glycoprotein 2 / Homo sapiens
  •        Asn-275
• Uromodulin / Homo sapiens
  •        Asn-513
• Platelet glycoprotein IV / Bos taurus
  •        Undefined site
• Uncharacterized protein from Milk Fat Globule Membrane / Bos taurus
  •        Undefined site
• Uncharacterized porcine zona pellucida glycoprotein / Sus scrofa
  •        Undefined site

Mass spectrometry observed peptide

• TAFITNFTLTIDGVTYPGNVK (21aa)
  •    Q06033    Asn-91
• LNSSTIK (7aa)
  •    P13473    Asn-275
• FALLMTNCYATPSSNATDPLK (21aa)
  •    P07911    Asn-513