Hex:7 HexNAc:4 NeuAc:1

Taxonomy

• Homo sapiens (Human)
• Mus musculus (House mouse)

Protein

• Alpha-1-antitrypsin / Homo sapiens    P01009
• CD59 glycoprotein / Homo sapiens    P13987
• Immunoglobulin heavy constant alpha 2 / Homo sapiens    P01877
• Lactadherin / Homo sapiens    Q08431
• Lactotransferrin / Homo sapiens    P02788
• Protein AMBP / Homo sapiens    P02760
• Fibrinogen beta chain / Mus musculus    Q8K0E8
• H-2 class I histocompatibility antigen, D-K alpha chain / Mus musculus    P14426
• Kininogen-1 / Mus musculus    O08677
• Mucin / Mus musculus    
• Pregnancy zone protein / Mus musculus    Q61838
• Serine protease inhibitor a3k / Mus musculus    P07759

Source

• Blood Serum (UBERON_0001977)  
• Brain (UBERON_0000955)  
• Milk (UBERON_0001913)  
• Submandibular Gland (UBERON_0001736)  
• Urine (UBERON_0001088)  
• Adipose-derived stem cells (ADSCs) (CL_0000136)  
• Differentiated Adipose-derived stem cells (dADSCs) (CL_0000136)  
• EBV-transformed B-cell (CL_0000236)  

Reported structure

• N-Linked / Hybrid / NeuAc(a2-3)Gal(b1-?)GlcNAc(b1-?)[Gal(b1-?)GlcNAc(b1-?)]Man(a1-?)[Man(a1-?)[Man(a1-?)]Man(a1-?)]Man(b1-4)GlcNAc(b1-4)GlcNAc
• N-Linked / Hybrid / Structure 9437
• N-Linked / Hybrid / Structure 9795
• N-Linked / Hybrid / Structure 10235

Composition

• Hex:7 HexNAc:4 NeuAc:1 (avg mass : 2257.05 )

Disease

• Control/Healthy
• Hyper IgE syndrome (HIES, p.Glu340del) (DOID:0080545)
• Prostate cancer (DOID:10283)

Reference

• Bisecting GlcNAc Protein N-Glycosylation Is Characteristic of Human Adipogenesis. (2020 - Katherine Wongtrakul-Kish, Benjamin R Herbert, Nicolle H Packer) / Status : Reviewed
• Quantitative Longitudinal Inventory of the N-Glycoproteome of Human Milk from a Single Donor Reveals the Highly Variable Repertoire and Dynamic Site-Specific Changes (2020 - Jing Zhu, Yu-Hsien Lin, Kelly A Dingess, Marko Mank, Bernd Stahl, Albert J R Heck) / Status : Reviewed
• Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis (2019 - Nicholas M. Riley, Alexander S. Hebert, Michael S. Westphall & Joshua J. Coon ) / Status : Unreviewed
• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed
• Efficient and accurate glycopeptide identification pipeline for high-throughput site-specific N-glycosylation analysis (2014 - Liu M, Zhang Y, Chen Y, Yan G, Shen C, Cao J, Zhou X, Liu X, Zhang L, Shen H, Lu H, He F, Yang P) / Status : Reviewed
• Hypomorphic homozygous mutations in phosphoglucomutase 3 (PGM3) impair immunity and increase serum IgE levels, (2014 - Atfa Sassi, Sandra Lazaroski, Gang Wu, Stuart M. Haslam, Manfred Fliegauf, Fethi Mellouli, Turkan Patiroglu, Ekrem Unal, Mehmet Akif Ozdemir, Zineb Jouhadi, Khadija Khadir, Leila Ben-Khemis, Meriem Ben-Ali, Imen Ben-Mustapha, Lamia Borchani, Dietmar Pfeifer, Thilo Jakob, Monia Khemiri, A. Charlotta Asplund, Manuela O. Gustafsson, Karin E. Lundin, Elin Falk-Sörqvist, Lotte N. Moens, Hatice Eke Gungor, Karin R. Engelhardt, Magdalena Dziadzio, Hans Stauss, Bernhard Fleckenstein, Rebecca Meier, Khairunnadiya Prayitno, Andrea Maul-Pavicic, Sandra Schaffer, Mirzokhid Rakhmanov, Philipp Henneke, Helene Kraus, Hermann Eibel, Uwe Kölsch, Sellama Nadifi, Mats Nilsson, Mohamed Bejaoui, Alejandro A. Schäffer, C.I. Edvard Smith, Anne Dell, Mohamed-Ridha Barbouche, Bodo Grimbacher) / Status : Reviewed
• Characterization of asparagine-linked oligosaccharides on a mouse submandibular mucin. (1995 - Denny P, Hong-Le N) / Status : Reviewed

Reported glycosite

• Alpha-1-antitrypsin / Homo sapiens
  •        Asn-271
• CD59 glycoprotein / Homo sapiens
  •        Asn-43
• Immunoglobulin heavy constant alpha 2 / Homo sapiens
  •        Asn-205
• Lactadherin / Homo sapiens
  •        Asn-329
• Lactotransferrin / Homo sapiens
  •        Asn-156
  •        Asn-497
• Protein AMBP / Homo sapiens
  •        Asn-250
• Fibrinogen beta chain / Mus musculus
  •        Asn-384
• H-2 class I histocompatibility antigen, D-K alpha chain / Mus musculus
  •        Asn-280
• Kininogen-1 / Mus musculus
  •        Asn-168
• Mucin / Mus musculus
  •        Undefined site
• Pregnancy zone protein / Mus musculus
  •        Asn-568
• Serine protease inhibitor a3k / Mus musculus
  •        Asn-270

Mass spectrometry observed peptide

• TAVNCSSDFDACLITK (16aa)
  •    P13987    Asn-43     CD59 glycoprotein / Homo sapiens
• RTAGWNVPIGTLRPFLNWTGPPEPIEAAVARF (32aa)
  •    P02788    Asn-156     Lactotransferrin / Homo sapiens
• RRTAGWNVPIGTLRPFLNWTGPPEPIEAAVARF (33aa)
  •    P02788    Asn-156     Lactotransferrin / Homo sapiens
• HSIEHFNNNTDHSHLFTLR (19aa)
  •    O08677    Asn-168     Kininogen-1 / Mus musculus
• YFYNGTSMACETFQYGGCMGNGNNFVTEK (29aa)
  •    P02760    Asn-250     Protein AMBP / Homo sapiens
• YTGNASALLILPDQGR (16aa)
  •    P07759    Asn-270     Serine protease inhibitor a3k / Mus musculus
• YLGNATAIFFLPDEGK (16aa)
  •    P01009    Asn-271     Alpha-1-antitrypsin / Homo sapiens
• EQNYTCHVYHEGLPEPLTLR (20aa)
  •    P14426    Asn-280     H-2 class I histocompatibility antigen, D-K alpha chain / Mus musculus
• KVAYSNDSANWTEYQDPRT (19aa)
  •    Q08431    Asn-329     Lactadherin / Homo sapiens
• YKGTAGNALMDGASQLVGENR (21aa)
  •    Q8K0E8    Asn-384     Fibrinogen beta chain / Mus musculus
• TAGWNIPMGLLFNQTGSCK (19aa)
  •    P02788    Asn-497     Lactotransferrin / Homo sapiens
• RTAGWNIPMGLLFNQTGSCKF (21aa)
  •    P02788    Asn-497     Lactotransferrin / Homo sapiens
• VNLSFPSAQSLPASDTHLK (19aa)
  •    Q61838    Asn-568     Pregnancy zone protein / Mus musculus