Hex:3 HexNAc:6 dHex:2 NeuAc:1

Taxonomy

• Homo sapiens (Human)

Protein

• Alpha-1-antitrypsin / Homo sapiens    P01009
• Alpha-S1-casein / Homo sapiens    P47710
• Apolipoprotein d / Homo sapiens    P05090
• Basement membrane-specific heparan sulfate proteoglycan core protein / Homo sapiens    P98160
• Biglycan / Homo sapiens    P21810
• Clusterin / Homo sapiens    P10909
• CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 / Homo sapiens    Q11201
• Coiled-coil domain-containing protein 138 / Homo sapiens    Q96M89
• Ephrin-A3 / Homo sapiens    P52797
• Fibronectin / Homo sapiens    P02751
• GDNF family receptor alpha-1 / Homo sapiens    P56159
• Glycodelin-a / Homo sapiens    P09466
• Golgi apparatus protein 1 / Homo sapiens    Q92896
• Golgi membrane protein 1 / Homo sapiens    Q8NBJ4
• Golgin subfamily A member 8A / Homo sapiens    A7E2F4
• Golgin subfamily A member 8B / Homo sapiens    A8MQT2
• Haptoglobin / Homo sapiens    P00738
• Immunoglobulin heavy constant alpha 2 / Homo sapiens    P01877
• Immunoglobulin heavy constant mu / Homo sapiens    P01871
• Interleukin-18-binding protein / Homo sapiens    O95998
• Interstitial collagenase / Homo sapiens    P03956
• Lactotransferrin / Homo sapiens    P02788
• Lumican / Homo sapiens    P51884
• N-acetylglucosamine-6-sulfatase / Homo sapiens    P15586
• Olfactomedin-like protein 3 / Homo sapiens    Q9NRN5
• Polymeric immunoglobulin receptor / Homo sapiens    P01833
• Prolactin-inducible protein / Homo sapiens    P12273
• Prolargin / Homo sapiens    P51888
• Prostaglandin-h2 d-isomerase / Homo sapiens    P41222
• Protein AMBP / Homo sapiens    P02760
• Telomere-associated protein RIF1 / Homo sapiens    Q5UIP0
• Transmembrane 9 superfamily member 3 / Homo sapiens    Q9HD45
• Uromodulin / Homo sapiens    P07911
• Vitamin k-dependent protein c / Homo sapiens    P04070
• YTH domain-containing family protein 3 / Homo sapiens    Q7Z739
• Zinc-alpha-2-glycoprotein / Homo sapiens    P25311

Source

• Acetabular Part of Hip Bone (UBERON_0001269)   HT-1080 (CVCL_0317)   Fibroblast (CL_0000057)  
• Amniotic Fluid (UBERON_0000173)  
• Blood Serum (UBERON_0001977)  
• Kidney (UBERON_0002113)   HEK293-EBNA (CVCL_6974)  
• Mammary Gland (UBERON_0001911)  
• Milk (UBERON_0001913)  
• Urine (UBERON_0001088)  

Reported structure

• N-Linked / Complex / Fuc(a1-3)[GalNAc(b1-4)]GlcNAc(b1-2)Man(a1-?)[GalNAc(b1-4)GlcNAc(b1-2)Man(a1-?)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc+"+ NeuAc"
• N-Linked / Complex / NeuAc(a2-6)GalNAc(b1-4)GlcNAc(b1-2)Man(a1-3)[Fuc(a1-3)[GalNAc(b1-4)]GlcNAc(b1-2)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc
• N-Linked / Complex / NeuAc(a2-6)GalNAc(b1-4)GlcNAc(b1-2)Man(a1-?)[Fuc(a1-3)[GalNAc(b1-4)]GlcNAc(b1-2)Man(a1-?)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc
• N-Linked / Complex / Structure 9484

Composition

• Hex:3 HexNAc:6 dHex:2 NeuAc:1 (avg mass : 2307.1564 )

Disease

• Cancer, breast (DOID:1612)
• Fibrosarcoma (DOID:3355)
• Oral squamous cell carcinoma (DOID:0050866)
• Prostate cancer (DOID:10283)

Reference

• Quantitative Longitudinal Inventory of the N-Glycoproteome of Human Milk from a Single Donor Reveals the Highly Variable Repertoire and Dynamic Site-Specific Changes (2020 - Jing Zhu, Yu-Hsien Lin, Kelly A Dingess, Marko Mank, Bernd Stahl, Albert J R Heck) / Status : Reviewed
• Tongue Cancer Patients Can be Distinguished from Healthy Controls by Specific N-Glycopeptides Found in Serum. (2018 - Mayank Saraswat, Antti Mäkitie, Tiialotta Tohmola, Amy Dickinson, Shruti Saraswat, Sakari Joenväärä, Suvi Renkonen) / Status : Reviewed
• Reanalysis of global proteomic and phosphoproteomic data identified a large number of glycopeptides (2018 - Yingwei Hu, Punit Shah, David J. Clark, Minghui Ao, Hui Zhang) / Status : Unreviewed
• Distinct urinary glycoprotein signatures in prostate cancer patients (2018 - Rebeca Kawahara, Fabio Ortega, Livia Rosa-Fernandes, Vanessa Guimarães, Daniel Quina, Willian Nahas, Veit Schwämmle, Miguel Srougi, Katia R.M. Leite, Morten Thaysen-Andersen, Martin R. Larsen and Giuseppe Palmisano) / Status : Unreviewed
• N-glycan structures of matrix metalloproteinase-1 derived from human fibroblasts and from HT-1080 fibrosarcoma cells. (1999 - Saarinen J, Welgus H, Flizar C, Kalkkinen N, Helin J) / Status : Reviewed
• Structural analysis of the oligosaccharides derived from glycodelin, a human glycoprotein with potent immunosuppressive and contraceptive activities. (1995 - Dell A, Morris H, Easton R, Panico M, Patankar M, Oehniger S, Koistinen R, Koistinen H, Seppala M, Clark G) / Status : Reviewed
• Novel Asn-linked oligosaccharides terminating in GalNAc beta (1-->4)[Fuc alpha (1-->3)]GlcNAc beta (1-->.) are present in recombinant human protein C expressed in human kidney 293 cells. (1993 - Yan S, Chao Y, van Halbeek H) / Status : Reviewed

Reported glycosite

• Alpha-1-antitrypsin / Homo sapiens
  •        Asn-271
• Alpha-S1-casein / Homo sapiens
  •        Asn-69
• Apolipoprotein d / Homo sapiens
  •        Asn-98
• Basement membrane-specific heparan sulfate proteoglycan core protein / Homo sapiens
  •        Asn-89
• Biglycan / Homo sapiens
  •        Asn-270
  •        Asn-311
• Clusterin / Homo sapiens
  •        Asn-374
• CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 / Homo sapiens
  •        Asn-114
• Coiled-coil domain-containing protein 138 / Homo sapiens
  •        Asn-279
• Ephrin-A3 / Homo sapiens
  •        Asn-100
• Fibronectin / Homo sapiens
  •        Asn-528
• GDNF family receptor alpha-1 / Homo sapiens
  •        Asn-59
• Glycodelin-a / Homo sapiens
  •        Asn-81
• Golgi apparatus protein 1 / Homo sapiens
  •        Asn-210
  •        Asn-581
• Golgi membrane protein 1 / Homo sapiens
  •        Asn-109
• Golgin subfamily A member 8A / Homo sapiens
  •        Asn-117
• Golgin subfamily A member 8B / Homo sapiens
  •        Asn-89
• Haptoglobin / Homo sapiens
  •        Asn-241
• Immunoglobulin heavy constant alpha 2 / Homo sapiens
  •        Asn-205
• Immunoglobulin heavy constant mu / Homo sapiens
  •        Asn-209
• Interleukin-18-binding protein / Homo sapiens
  •        Asn-147
• Interstitial collagenase / Homo sapiens
  •        Asn-120
• Lactotransferrin / Homo sapiens
  •        Asn-156
• Lumican / Homo sapiens
  •        Asn-127
• N-acetylglucosamine-6-sulfatase / Homo sapiens
  •        Asn-422
• Olfactomedin-like protein 3 / Homo sapiens
  •        Asn-248
• Polymeric immunoglobulin receptor / Homo sapiens
  •        Asn-90
• Prolactin-inducible protein / Homo sapiens
  •        Asn-105
• Prolargin / Homo sapiens
  •        Asn-124
• Prostaglandin-h2 d-isomerase / Homo sapiens
  •        Asn-51
  •        Asn-78
• Protein AMBP / Homo sapiens
  •        Asn-250
• Telomere-associated protein RIF1 / Homo sapiens
  •        Asn-105
• Transmembrane 9 superfamily member 3 / Homo sapiens
  •        Asn-174
• Uromodulin / Homo sapiens
  •        Asn-513
• Vitamin k-dependent protein c / Homo sapiens
  •        Undefined site
• YTH domain-containing family protein 3 / Homo sapiens
  •        Asn-175
• Zinc-alpha-2-glycoprotein / Homo sapiens
  •        Asn-109

Mass spectrometry observed peptide

• WFSAGLASNSSWLR (14aa)
  •    P41222    Asn-51
• ETNFSIASGIEAK (13aa)
  •    P56159    Asn-59
• RNESTQNCVVAEPEKM (16aa)
  •    P47710    Asn-69
• SVVAPATDGGLNLTSTFLR (19aa)
  •    P41222    Asn-78
• AIVNFTR (7aa)
  •    P98160    Asn-89
• RANLTNFPENGTFVVNIAQLSQDDSGRY (28aa)
  •    P01833    Asn-90
• ADGTVNQIEGEATPVNLTEPAKLEVK (26aa)
  •    P05090    Asn-98
• TCNASQGFK (9aa)
  •    P52797    Asn-100
• TFYWDFYTNR (10aa)
  •    P12273    Asn-105
• LNDTLK (6aa)
  •    Q11201    Asn-114
  •    Q96M89    Asn-279
  •    Q5UIP0    Asn-105
  •    A7E2F4    Asn-117
  •    A8MQT2    Asn-89
• DIVEYYNDSNGSHVIQGR (18aa)
  •    P25311    Asn-109
• AVIVNNITTGER (12aa)
  •    Q8NBJ4    Asn-109
• IHYLYLQNNFITELPVESFQNATGLR (26aa)
  •    P51888    Asn-124
• KLHINHNNLTESVGPLPK (18aa)
  •    P51884    Asn-127
• LHINHNNLTESVGPLPK (17aa)
  •    P51884    Asn-127
• ALVLEQLTPALHSTNFSCVLVDPEQVVQR (29aa)
  •    O95998    Asn-147
• RRTAGWNVPIGTLRPFLNWTGPPEPIEAAVARF (33aa)
  •    P02788    Asn-156
• NLTSEGK (7aa)
  •    Q9HD45    Asn-174
• AITDGQAGFGNDTLSK (16aa)
  •    Q7Z739    Asn-175
• TPLTANITK (9aa)
  •    P01877    Asn-205
• GITFQQNASSMCVPDQDTAIR (21aa)
  •    P01871    Asn-209
• GNITEYQCHQYITK (14aa)
  •    Q92896    Asn-210
• VVLHPNYSQVDIGLIK (16aa)
  •    P00738    Asn-241
• FHLANR (6aa)
  •    Q9NRN5    Asn-248
• YFYNGTSMACETFQYGGCMGNGNNFVTEK (29aa)
  •    P02760    Asn-250
• MIENGSISFIPTIR (14aa)
  •    P21810    Asn-270
• YIGNATAIFFIPDEGK (16aa)
  •    P01009    Asn-271
• IIQVVYIHSNNITK (14aa)
  •    P21810    Asn-311
• IANITQGEDQYYIR (14aa)
  •    P10909    Asn-374
• NVTDPTCPSLSPGVSQCFPDCVCEDAYNNTYACVR (35aa)
  •    P15586    Asn-422
• FALLMTNCYATPSSNATDPLK (21aa)
  •    P07911    Asn-513
• DQCIVDDITYNVNDTFHK (18aa)
  •    P02751    Asn-528
• ICHTHGWNETSEFMPQGAVFSCIYR (25aa)
  •    Q92896    Asn-581