Hex:7 HexNAc:7 dHex:1 NeuAc:1

Taxonomy

• Homo sapiens (Human)

Protein

• Carcinoembryonic antigen-related cell adhesion molecule 5 / Homo sapiens    P06731
• Immunoglobulin epsilon chain c region / Homo sapiens    P01854

Source

• Ascitic fluid (UBERON_0007795)  
• Colon (UBERON_0001155)  
• HEK293T (CVCL_0063)  
• LS174T (CVCL_1384)  
• EBV-transformed B-cell (CL_0000236)  

Reported structure

• N-Linked / Complex / Structure 10137
• N-Linked / Complex / Structure 10165
• N-Linked / Complex / Structure 10182
• N-Linked / Complex / Structure 10431
• N-Linked / Complex / Structure 10507
• N-Linked / Complex / Structure 10575

Composition

• Hex:7 HexNAc:7 dHex:1 NeuAc:1 (avg mass : 3012.778 )

Disease

• Colon adenocarcinoma (DOID:234)
• Control/Healthy
• Hyper IgE syndrome (HIES, p.Glu340del) (DOID:0080545)
• Hyper IgE syndrome (HIES, p.Leu83Ser) (DOID:0080545)

Reference

• Carcinoembryonic antigen glycosylation (2021 - Kolarich D) / Status : Reviewed
• A single glycan on IgE is indispensable for initiation of anaphylaxis (2015 - Kai-Ting C. Shade, Barbara Platzer, Nathaniel Washburn, Vinidhra Mani, Yannic C. Bartsch, Michelle Conroy, Jose D. Pagan, Carlos Bosques, Thorsten R. Mempel, Edda Fiebiger, Robert M. Anthony) / Status : Reviewed
• Hypomorphic homozygous mutations in phosphoglucomutase 3 (PGM3) impair immunity and increase serum IgE levels, (2014 - Atfa Sassi, Sandra Lazaroski, Gang Wu, Stuart M. Haslam, Manfred Fliegauf, Fethi Mellouli, Turkan Patiroglu, Ekrem Unal, Mehmet Akif Ozdemir, Zineb Jouhadi, Khadija Khadir, Leila Ben-Khemis, Meriem Ben-Ali, Imen Ben-Mustapha, Lamia Borchani, Dietmar Pfeifer, Thilo Jakob, Monia Khemiri, A. Charlotta Asplund, Manuela O. Gustafsson, Karin E. Lundin, Elin Falk-Sörqvist, Lotte N. Moens, Hatice Eke Gungor, Karin R. Engelhardt, Magdalena Dziadzio, Hans Stauss, Bernhard Fleckenstein, Rebecca Meier, Khairunnadiya Prayitno, Andrea Maul-Pavicic, Sandra Schaffer, Mirzokhid Rakhmanov, Philipp Henneke, Helene Kraus, Hermann Eibel, Uwe Kölsch, Sellama Nadifi, Mats Nilsson, Mohamed Bejaoui, Alejandro A. Schäffer, C.I. Edvard Smith, Anne Dell, Mohamed-Ridha Barbouche, Bodo Grimbacher) / Status : Reviewed

Reported glycosite

• Carcinoembryonic antigen-related cell adhesion molecule 5 / Homo sapiens
  •        Undefined site
  •        Asn-288
• Immunoglobulin epsilon chain c region / Homo sapiens
  •        Asn-21
  •        Asn-49
  •        Asn-99
  •        Asn-146

Mass spectrometry observed peptide

• IPNIT (5aa)
  •    P06731    Asn-288     Carcinoembryonic antigen-related cell adhesion molecule 5 / Homo sapiens