Hex:6 HexNAc:4 NeuAc:2

Taxonomy

• Homo sapiens (Human)

Protein

• 4F2 cell-surface antigen heavy chain / Homo sapiens    P08195
• Adhesion G protein-coupled receptor L4 / Homo sapiens    Q9HBW9
• Alpha-1-antitrypsin / Homo sapiens    P01009
• Alpha-2-macroglobulin / Homo sapiens    P01023
• Apolipoprotein F / Homo sapiens    Q13790
• Beta-2-glycoprotein 1 / Homo sapiens    P02749
• Cation-independent mannose-6-phosphate receptor / Homo sapiens    P11717
• Ceruloplasmin / Homo sapiens    P00450
• Clusterin / Homo sapiens    P10909
• Fibrillin-1 / Homo sapiens    P35555
• Haptoglobin / Homo sapiens    P00738
• Immunoglobulin heavy constant gamma 1 / Homo sapiens    P01857
• Immunoglobulin heavy constant gamma 4 / Homo sapiens    P01861
• Immunoglobulin heavy constant mu / Homo sapiens    P01871
• Laminin subunit alpha-2 / Homo sapiens    P24043
• Neural cell adhesion molecule L1-like protein / Homo sapiens    O00533
• Phospholipase D4 / Homo sapiens    Q96BZ4
• Plasma protease c1 inhibitor / Homo sapiens    P05155
• Platelet-derived growth factor receptor beta / Homo sapiens    P09619
• Plexin-B2 / Homo sapiens    O15031
• Prostate-specific antigen - high Pi isoform (psah) / Homo sapiens    P07288
• Protein heg homolog 1 / Homo sapiens    Q9ULI3
• Serotransferrin / Homo sapiens    P02787
• Sialic acid-binding Ig-like lectin 14 / Homo sapiens    Q08ET2
• Stabilin-1 / Homo sapiens    Q9NY15
• Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 / Homo sapiens    Q4LDE5

Source

• Ascitic fluid (UBERON_0007795)  
• Blood Serum (UBERON_0001977)  
• Bone Marrow (UBERON_0002371)  
• Seminal Fluid (UBERON_0006530)  
• Umbilical Vein (UBERON_0002066)   Endothelial Cell of Umbilical Vein (CL_0002618)  
• Urine (UBERON_0001088)  

Reported structure

• N-Linked / Complex / Gal(b1-4)GlcNAc(b1-2)[Gal(b1-4)GlcNAc(b1-4)]Man(a1-3)[Gal(b1-4)GlcNAc(b1-2)Man(a1-6)]Man(b1-4)GlcNAc+"+ 2 x NeuAc"
• N-Linked / Complex / NeuAc(a2-?)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)GlcNAc(b1-2)Man(a1-?)[NeuAc(a2-?)Gal(b1-4)GlcNAc(b1-2)Man(a1-?)]Man(b1-4)GlcNAc
• N-Linked / Hybrid / Structure 10669

Composition

• Hex:6 HexNAc:4 NeuAc:2 (avg mass : 2386.1655 )

Disease

• Control/Healthy
• Infantile Sialidosis, Type II (Dysmorphic) (DOID:3343)
• Mixed phenotype acute leukemia (DOID:9953)
• Prostate cancer (DOID:10283)
• Sialidosis, severe infantile with abdominal ascites (DOID:3343)

Reference

• B-cell precursor acute lymphoblastic leukemia with MLL rearrangement shows extensive glycomic-related changes (2021 - Oliveira T) / Status : Reviewed
• Large-scale intact glycopeptide identification by Mascot database search (2018 - Ravi Chand Bollineni, Christian Jeffrey Koehler, Randi Elin Gislefoss, Jan Haug Anonsen, Bernd Thiede) / Status : Unreviewed
• Glycoproteomics: Identifying the Glycosylation of Prostate Specific Antigen at Normal and High Isoelectric Points by LC-MS/MS (2014 - Song E, Mayampurath A, Yu CY, Tang H, Mechref Y) / Status : Reviewed
• Efficient and accurate glycopeptide identification pipeline for high-throughput site-specific N-glycosylation analysis (2014 - Liu M, Zhang Y, Chen Y, Yan G, Shen C, Cao J, Zhou X, Liu X, Zhang L, Shen H, Lu H, He F, Yang P) / Status : Reviewed
• Glycoproteomic analysis of the secretome of human endothelial cells (2013 - Yin X, Bern M, Xing Q, Ho J, Viner R, Mayr M.) / Status : Reviewed
• Severe infantile sialidosis--the characteristics of oligosaccharides isolated from the urine and the abdominal ascites. (1992 - Nakamura Y, Takahashi Y, Yamaguchi S, Omiya S, Orii T, Yara A, Gushiken M) / Status : Reviewed
• A comparative study of sialyloligosaccharides isolated from sialidosis and galactosialidosis urine. (1991 - van Pelt J, Kamerling J, Bakker H, Vliegenthart J) / Status : Reviewed

Reported glycosite

• 4F2 cell-surface antigen heavy chain / Homo sapiens
  •        Asn-365
• Adhesion G protein-coupled receptor L4 / Homo sapiens
  •        Asn-177
• Alpha-1-antitrypsin / Homo sapiens
  •        Asn-271
• Alpha-2-macroglobulin / Homo sapiens
  •        Asn-1424
• Apolipoprotein F / Homo sapiens
  •        Asn-118
• Beta-2-glycoprotein 1 / Homo sapiens
  •        Asn-162
• Cation-independent mannose-6-phosphate receptor / Homo sapiens
  •        Asn-67
• Ceruloplasmin / Homo sapiens
  •        Asn-397
• Clusterin / Homo sapiens
  •        Asn-374
• Fibrillin-1 / Homo sapiens
  •        Asn-1067
• Haptoglobin / Homo sapiens
  •        Asn-241
• Immunoglobulin heavy constant gamma 1 / Homo sapiens
  •        Asn-180
• Immunoglobulin heavy constant gamma 4 / Homo sapiens
  •        Asn-177
• Immunoglobulin heavy constant mu / Homo sapiens
  •        Asn-209
• Laminin subunit alpha-2 / Homo sapiens
  •        Asn-2045
• Neural cell adhesion molecule L1-like protein / Homo sapiens
  •        Asn-1197
• Phospholipase D4 / Homo sapiens
  •        Asn-403
• Plasma protease c1 inhibitor / Homo sapiens
  •        Asn-253
• Platelet-derived growth factor receptor beta / Homo sapiens
  •        Asn-371
• Plexin-B2 / Homo sapiens
  •        Asn-1049
• Prostate-specific antigen - high Pi isoform (psah) / Homo sapiens
  •        Asn-69
• Protein heg homolog 1 / Homo sapiens
  •        Asn-1101
• Serotransferrin / Homo sapiens
  •        Asn-630
• Sialic acid-binding Ig-like lectin 14 / Homo sapiens
  •        Asn-247
• Stabilin-1 / Homo sapiens
  •        Asn-1178
• Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 / Homo sapiens
  •        Asn-3018

Mass spectrometry observed peptide

• INICGSVDIVQCGPSSAVCMHDLK (24aa)
  •    P11717    Asn-67     Cation-independent mannose-6-phosphate receptor / Homo sapiens
• NKSVLLGR (8aa)
  •    P07288    Asn-69     Prostate-specific antigen - high Pi isoform (psah) / Homo sapiens
• QGGVNATQVLIQHLR (15aa)
  •    Q13790    Asn-118     Apolipoprotein F / Homo sapiens
• VYKPSAGNNSLYR (13aa)
  •    P02749    Asn-162     Beta-2-glycoprotein 1 / Homo sapiens
• NNTISAK (7aa)
  •    Q9HBW9    Asn-177     Adhesion G protein-coupled receptor L4 / Homo sapiens
• GLTFQQNASSMCVPDQDTAIR (21aa)
  •    P01871    Asn-209     Immunoglobulin heavy constant mu / Homo sapiens
• VVLHPNYSQVDIGLIK (16aa)
  •    P00738    Asn-241     Haptoglobin / Homo sapiens
• NGTGTALR (8aa)
  •    Q08ET2    Asn-247     Sialic acid-binding Ig-like lectin 14 / Homo sapiens
• VLSNNSDANLELINTWVAK (19aa)
  •    P05155    Asn-253     Plasma protease c1 inhibitor / Homo sapiens
• YLGNATAIFFLPDEGK (16aa)
  •    P01009    Asn-271     Alpha-1-antitrypsin / Homo sapiens
• DASSFLAEWQNITK (14aa)
  •    P08195    Asn-365     4F2 cell-surface antigen heavy chain / Homo sapiens
• NVSETR (6aa)
  •    P09619    Asn-371     Platelet-derived growth factor receptor beta / Homo sapiens
• LANLTQGEDQYYLR (14aa)
  •    P10909    Asn-374     Clusterin / Homo sapiens
• ENLTAPGSDSAVFFEQGTTR (20aa)
  •    P00450    Asn-397     Ceruloplasmin / Homo sapiens
• SLQALSNPAANVSVDVK (17aa)
  •    Q96BZ4    Asn-403     Phospholipase D4 / Homo sapiens
• QQQHLFGSNVTDCSGNFCLFR (21aa)
  •    P02787    Asn-630     Serotransferrin / Homo sapiens
• EAESLQPMTVVGTDYVFHNDTK (22aa)
  •    O15031    Asn-1049     Plexin-B2 / Homo sapiens
• NCTDIDECR (9aa)
  •    P35555    Asn-1067     Fibrillin-1 / Homo sapiens
• TLNMCFSALPSYIR (14aa)
  •    Q9ULI3    Asn-1101     Protein heg homolog 1 / Homo sapiens
• GSVESNGSSTATFPLR (16aa)
  •    O00533    Asn-1197     Neural cell adhesion molecule L1-like protein / Homo sapiens
• VSNQTLSLFFTVLQDVPVR (19aa)
  •    P01023    Asn-1424     Alpha-2-macroglobulin / Homo sapiens
• QANDTAK (7aa)
  •    P24043    Asn-2045     Laminin subunit alpha-2 / Homo sapiens
• CSTPVIEYGTVNGTDFDCGK (20aa)
  •    Q4LDE5    Asn-3018     Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 / Homo sapiens