Cell line BeWo

Taxonomy

• Homo sapiens (Human)

Protein

• Choriogonadotropin beta chain / Homo sapiens    P0DN86
• Transferrin receptor protein 1 / Homo sapiens    P02786

Source

• Placenta (UBERON_0001987)   BeWo (CVCL_0044)   Epithelium (CL_0002577)  

Reported structure

• O-Linked / Core 0 / GalNAc
• O-Linked / Core 1 / NeuAc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GalNAc
• O-Linked / Core 2 / NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-3)]GalNAc
• O-Linked / Core 2 / NeuAc(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-3)]GalNAc
• O-Linked / Core 2 / NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-3)[NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-6)]GalNAc
• O-Linked / Undefined core / Gal(?1-?)GalNAc

Composition

• HexNAc:1 (avg mass : 221.2103 )
• Hex:1 HexNAc:1 (avg mass : 383.3527 )
• Hex:1 HexNAc:1 NeuAc:2 (avg mass : 965.8685 )
• Hex:2 HexNAc:2 NeuAc:2 (avg mass : 1331.2059 )
• Hex:2 HexNAc:2 dHex:1 NeuAc:2 (avg mass : 1477.3489 )
• Hex:3 HexNAc:3 NeuAc:2 (avg mass : 1696.5433 )

Disease

• Choriocarcinoma (DOID:3594)

Reference

• The carbohydrate chains of the beta subunit of human chorionic gonadotropin produced by the choriocarcinoma cell line BeWo. Novel O-linked and novel bisecting-GlcNAc-containing N-linked carbohydrates. (1992 - Hard K, Damm J, Spruijt M, Bergwerff A, Kamerling J, Van Dedem G, Vliegenthart J) / Status : Reviewed
• Human transferrin receptor contains O-linked oligosaccharides. (1990 - Do S, Enns C, Cummings R) / Status : Reviewed

Reported glycosite

• Choriogonadotropin beta chain / Homo sapiens
  •        Undefined site
• Transferrin receptor protein 1 / Homo sapiens
  •        Undefined site

Mass spectrometry observed peptide