Cell line Lec8

Taxonomy

• Cricetulus griseus (Chinese hamster)
• Hybrid - homo sapiens/mus musculus (Hybrid - human/mouse)

Protein

• Notch 1 / Cricetulus griseus
• Immunoglobulin gamma-1 / Hybrid - homo sapiens/mus musculus

Source

• Ovary (UBERON_0000992)   Lec8 (CVCL_3443)  

Reported structure

• N-Linked/O-Linked / No-core / Glc
• O-Linked / No-core / Xyl(a1-3)Xyl(a1-3)Glc
• N-Linked / Complex / GlcNAc(b1-2)Man(a1-3)[GlcNAc(b1-2)Man(a1-6)]Man(b1-4)GlcNAc(b1-4)[Fuc(a1-6)]GlcNAc

Composition

• Hex:1 (avg mass : 180.1577 )
• Hex:1 Pent:2 (avg mass : 444.3899 )
• Hex:3 HexNAc:4 dHex:1 (avg mass : 1463.3655 )

Disease

Reference

• Mammalian Notch1 is modified with two unusual forms of O-linked glycosylation found on epidermal growth factor-like modules. (2000 - Moloney D, Shair L, Lu F, Xia J, Locke R, Matta K, Haltiwanger R) / Status : Reviewed
• In vivo trafficking and catabolism of IgG1 antibodies with Fc associated carbohydrates of differing structure. (2000 - Wright A, Sato Y, Okada T, Chang K, Endo T, Morrison S) / Status : Reviewed

Reported glycosite

• Notch 1 / Cricetulus griseus
  •        Undefined site
• Immunoglobulin gamma-1 / Hybrid - homo sapiens/mus musculus
  •        Undefined site

Mass spectrometry observed peptide