Cell line LOVO

Taxonomy

• Homo sapiens (Human)

Protein

Source

• LOVO (CVCL_0399)  

Reported structure

• O-Linked / Core 1 / NeuAc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GalNAc
• O-Linked / Core 2 / Gal(b1-4)GlcNAc(b1-6)[Gal(b1-3)]GalNAc
• O-Linked / Core 2 / Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-3)]GalNAc
• O-Linked / Core 2 / NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-6)[Gal(b1-3)]GalNAc
• O-Linked / Core 2 / Structure 11038
• O-Linked / Core 2 / NeuAc(a2-3)Gal(b1-?)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-3)]GalNAc
• O-Linked / Core 2 / Structure 11081
• O-Linked / Core 4 / Structure 11052

Composition

• Hex:1 HexNAc:1 NeuAc:2 (avg mass : 965.8685 )
• Hex:1 HexNAc:3 dHex:1 NeuAc:1 (avg mass : 1227.1436 )
• Hex:2 HexNAc:2 (avg mass : 748.6901 )
• Hex:2 HexNAc:2 NeuAc:1 (avg mass : 1039.948 )
• Hex:2 HexNAc:2 NeuAc:2 (avg mass : 1331.2059 )
• Hex:3 HexNAc:2 dHex:1 (avg mass : 1056.9755 )
• Hex:3 HexNAc:4 NeuAc:2 (avg mass : 1899.7383 )
• Hex:4 HexNAc:4 NeuAc:2 (avg mass : 2061.8807 )
• Hex:4 HexNAc:4 NeuAc:3 (avg mass : 2353.1386 )

Disease

• Colon adenocarcinoma (DOID:234)

Reference

• Colorectal cancer cell lines show striking diversity of their O-glycome reflecting the cellular differentiation phenotype (2021 - Katarina Madunić, Tao Zhang, Oleg A Mayboroda, Stephanie Holst, Kathrin Stavenhagen, Chunsheng Jin, Niclas G Karlsson, Guinevere S M Lageveen-Kammeijer, Manfred Wuhrer) / Status : Reviewed

Reported glycosite

Mass spectrometry observed peptide