Cell line Caco-2

Taxonomy

• Homo sapiens (Human)

Protein

• Muc1f (delta tr) / Homo sapiens    P15941
• Recombinant Mucin-1 Muc1f (delta tr) / Homo sapiens    P15941
• Recombinant Mucin-1 Muc1f/2tr / Homo sapiens    P15941    Q02817
• Recombinant Mucin-1 Muc1f/4tr / Homo sapiens    P15941    Q99102
• Recombinant Mucin-1 Muc1f/5actr / Homo sapiens    P15941    P98088
• Recombinant Mucin-1 Muc1f/5btr / Homo sapiens    P15941    Q9HC84

Source

• Colon (UBERON_0001155)   Caco-2 (CVCL_0025)  
• Caco-2 (CVCL_0025)  

Reported structure

• O-Linked / Core 1 / Gal(b1-3)GalNAc
• O-Linked / Core 1 / Fuc(a1-2)Gal(b1-3)GalNAc
• O-Linked / Core 1 / Gal(b1-3)GalNAc+"+ NeuAc(a2-?)"
• O-Linked / Core 1 / NeuAc(a2-3)Gal(b1-3)GalNAc
• O-Linked / Core 1 / NeuAc(a2-?)Gal(b1-3)[NeuAc(a2-6)]GalNAc
• O-Linked / Core 1 / GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-3)[NeuAc(a2-6)]GalNAc
• O-Linked / Core 2 / Gal(b1-4)GlcNAc(b1-6)[Gal(b1-3)]GalNAc
• O-Linked / Core 2 / Fuc(a1-2)Gal(b1-3)[Gal(b1-4)GlcNAc(b1-6)]GalNAc
• O-Linked / Core 2 / Fuc(a1-2)Gal(b1-4)GlcNAc(b1-6)[Gal(b1-3)]GalNAc
• O-Linked / Core 2 / Gal(b1-4)GlcNAc(b1-6)[Gal(b1-3)]GalNAc+"+ Fuc(a1-2)"
• O-Linked / Core 2 / Gal(b1-4)GlcNAc(b1-6)[Gal(b1-3)]GalNAc+"+ NeuAc(a2-?)"
• O-Linked / Core 2 / Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-3)]GalNAc
• O-Linked / Core 2 / NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-6)[Gal(b1-3)]GalNAc
• O-Linked / Core 2 / Fuc(a1-2)Gal(b1-4)GlcNAc(b1-6)[Fuc(a1-2)Gal(b1-3)]GalNAc
• O-Linked / Core 2 / Fuc(a1-2)Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-3)]GalNAc
• O-Linked / Core 2 / Gal(b1-4)GlcNAc(b1-6)[Gal(b1-3)]GalNAc+"+ Fuc(a1-2) + NeuAc(a2-?)"
• O-Linked / Core 2 / NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-6)[Fuc(a1-2)Gal(b1-3)]GalNAc
• O-Linked / Core 2 / Structure 11050
• O-Linked / Core 2 / NeuAc(a2-3)Gal(b1-?)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-3)]GalNAc
• O-Linked / Core 2 / NeuAc(a2-?)Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-?)Gal(b1-3)]GalNAc
• O-Linked / Core 2 / Structure 11068
• O-Linked / Core 2 / Structure 11100
• O-Linked / Core 2 / Structure 11035
• O-Linked / Undefined core / Gal(b1-3)GalNAc+"+ GlcNAc(?1-?)"
• O-Linked / Undefined core / Gal(b1-3)GalNAc+"+ 2 x Gal(b1-4)GlcNAc(b1-?)"

Composition

• Hex:1 HexNAc:1 (avg mass : 383.3527 )
• Hex:1 HexNAc:1 NeuAc:1 (avg mass : 674.6106 )
• Hex:1 HexNAc:1 NeuAc:2 (avg mass : 965.8685 )
• Hex:1 HexNAc:1 dHex:1 (avg mass : 529.4957 )
• Hex:1 HexNAc:2 (avg mass : 586.5477 )
• Hex:1 HexNAc:2 NeuAc:2 (avg mass : 1169.0635 )
• Hex:2 HexNAc:2 (avg mass : 748.6901 )
• Hex:2 HexNAc:2 NeuAc:1 (avg mass : 1039.948 )
• Hex:2 HexNAc:2 NeuAc:2 (avg mass : 1331.2059 )
• Hex:2 HexNAc:2 dHex:1 (avg mass : 894.8331 )
• Hex:2 HexNAc:2 dHex:1 NeuAc:1 (avg mass : 1186.091 )
• Hex:2 HexNAc:2 dHex:2 (avg mass : 1040.9761 )
• Hex:2 HexNAc:3 NeuAc:1 (avg mass : 1243.143 )
• Hex:2 HexNAc:3 NeuAc:2 (avg mass : 1534.4009 )
• Hex:2 HexNAc:3 dHex:1 NeuAc:1 (avg mass : 1389.286 )
• Hex:2 HexNAc:4 NeuAc:2 (avg mass : 1737.5959 )
• Hex:3 HexNAc:3 (avg mass : 1114.0275 )

Disease

• Adenocarcinoma (DOID:299)
• Colon adenocarcinoma (DOID:234)

Reference

• Colorectal cancer cell lines show striking diversity of their O-glycome reflecting the cellular differentiation phenotype (2021 - Katarina Madunić, Tao Zhang, Oleg A Mayboroda, Stephanie Holst, Kathrin Stavenhagen, Chunsheng Jin, Niclas G Karlsson, Guinevere S M Lageveen-Kammeijer, Manfred Wuhrer) / Status : Reviewed
• In vivo glycosylation of mucin tandem repeats (2001 - Silverman, Parry, Sutton-Smith, Burdick, McDermott, Reid, Batra, Morris, Hollingsworth, Dell, Harris) / Status : Reviewed

Reported glycosite

• Muc1f (delta tr) / Homo sapiens
  •        Undefined site
• Recombinant Mucin-1 Muc1f (delta tr) / Homo sapiens
  •        Undefined site
• Recombinant Mucin-1 Muc1f/2tr / Homo sapiens
  •        Undefined site
• Recombinant Mucin-1 Muc1f/4tr / Homo sapiens
  •        Undefined site
• Recombinant Mucin-1 Muc1f/5actr / Homo sapiens
  •        Undefined site
• Recombinant Mucin-1 Muc1f/5btr / Homo sapiens
  •        Undefined site

Mass spectrometry observed peptide