Chromaffin Granules

Taxonomy

• Bos taurus (Bovine)

Protein

• Chromogranin a / Bos taurus    P05059
• Uncharacterized protein from Chromaffin Granules / Bos taurus

Source

• Chromaffin Granules (GO_0042583)  

Reported structure

• O-Linked / Core 1 / Gal(b1-3)GalNAc
• O-Linked / Core 1 / NeuAc(a2-3)Gal(b1-3)GalNAc
• O-Linked / Core 1 / NeuGc(a2-3)Gal(b1-3)GalNAc
• O-Linked / Core 1 / Gal(b1-3)[NeuAc(a2-8)NeuAc(a2-6)]GalNAc
• O-Linked / Core 1 / NeuAc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GalNAc
• O-Linked / Core 1 / Gal(b1-3)[NeuGc(a2-8)NeuAc(a2-6)]GalNAc
• O-Linked / Core 1 / NeuAc(a2-3)Gal(b1-3)[NeuGc(a2-6)]GalNAc
• O-Linked / Core 1 / NeuGc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GalNAc
• O-Linked / Core 1 / NeuGc(a2-3)Gal(b1-3)[NeuGc(a2-6)]GalNAc
• O-Linked / Core 1 / NeuGc(a2-8)NeuGc(a2-6)[Gal(b1-3)]GalNAc
• O-Linked / Undefined core / Gal(?1-?)GalNAc
• O-Linked / Undefined core / Gal(?1-?)GalNAc+"+ NeuAc"
• O-Linked / Undefined core / Gal(?1-?)GalNAc+"+ NeuGc"
• O-Linked / Undefined core / NeuAc(?2-?)Gal(?1-?)[NeuAc(?2-?)]GalNAc
• O-Linked / Undefined core / Gal(?1-?)GalNAc+"+ NeuAc + NeuGc"
• O-Linked / Undefined core / NeuGc(?2-?)Gal(?1-?)[NeuGc(?2-?)]GalNAc

Composition

• Hex:1 HexNAc:1 (avg mass : 383.3527 )
• Hex:1 HexNAc:1 NeuGc:1 (avg mass : 690.61 )
• Hex:1 HexNAc:1 NeuGc:2 (avg mass : 997.8673 )
• Hex:1 HexNAc:1 NeuAc:1 (avg mass : 674.6106 )
• Hex:1 HexNAc:1 NeuAc:1 NeuGc:1 (avg mass : 981.8679 )
• Hex:1 HexNAc:1 NeuAc:2 (avg mass : 965.8685 )

Disease

Reference

• Chromogranin A from bovine adrenal medulla: molecular characterization of glycosylations, phosphorylations, and sequence heterogeneities by mass spectrometry. (1999 - Bauer S, Zhang X, Van Dongen W, Claeys M, Przybylski M) / Status : Reviewed
• Phosphorylation and O-glycosylation sites of bovine chromogranin A from adrenal medullary chromaffin granules and their relationship with biological activities. (1997 - Strub J, Sorokine O, Van Dorsselaer A, Aunis D, Metz-Boutigue M) / Status : Reviewed
• Antibacterial activity of glycosylated and phosphorylated chromogranin A-derived peptide 173-194 from bovine adrenal medullary chromaffin granules. (1996 - Strub J, Goumon Y, Lugardon K, Capon C, Lopez M, Moniatte M, Van Dorsselaer A, Aunis D, Metz-Boutigue M) / Status : Reviewed
• Glycoproteins and proteoglycans of the chromaffin granule matrix. (1982 - Kiang W-L, Krusius T, Finne J, Margolis RU, Margolis RK) / Status : Reviewed

Reported glycosite

• Chromogranin a / Bos taurus
  •        Ser-185
  •        Ser-204
  •        Thr-249
• Uncharacterized protein from Chromaffin Granules / Bos taurus
  •        Undefined site

Mass spectrometry observed peptide